CF Carrier Question

[anonymous]

Hi. I hope that I'm posting in the right place and someone can give me some info. I was just told that I have a mutation on one of my genes. I'm assuming this makes me only a carrier. I'm trying to get pregnant and have a lot of other infertilty issues like PCOS/insulin. My husband is now being tested to make sure he isn't a carrier also. Does anyone know what the chances are of him being a carrier also? I'm so overwhlemed by everything that's happenned the past few months with trying to conceive and losing a baby. And now this is another thing to top it off. I hope you can help and I'm sorry if I have posted in the wrong place.Thanks.Angela

 

[anonymous]

You found the right place to ask! I am not exactly sure how likely your husband is a carrier. It also depends on your race. A caucasian is more likely to be a carrier than other races. I am sure someone here knows the actual stats. If you have a mutation then you are a carrier. Even if your husband IS a carrier then you have a 50% chance of having a baby with cystic fibrosis, a 25% chance of having a baby that is just a carrier (like you), and a 25% chance of having a baby withOUT CF and who is NOT a carrier. I am sure someone else can help you out a little more than I can, but I thought I would give you a little bit of information.

 

[anonymous]

Thanks for the info. We are both caucasian and I think I read somewhere that the likelihood of a caucasian couple both being carriers is like 1 in 841. I don't know how true that is, but I'm hanging on to that. His grandparents are British and I know I read something about European desent. You can tell I'm a psycho, huh? I will just suffer through until Thurs and hopefully the results will be in. Thanks for the info!!

 

[anonymous]

Angela, So let me get this straight... neither you nor your husband have cystic fibrosis, and you just discovered you carry the gene for it, right? Your concern is whether or not he's a carrier of the cf gene and what your odds are for having children with the actual disease? The only way to tell if he's a carrier is to get tested for it (as you are currently doing). If he does carry the gene for cf, and you are also a carrier of this gene then the odds go like this:25% chance of passing on nothing, not even the carrier genes50% chance of passing on at least one carrier gene, but not the disease itself25% chance of passing on cystic fibrosis to your child (which automatically makes the child a carrier)Hope this helps....

 

[Drea]

Hi,That first reply is partly right about the chances if you are both carriers, it is: a 50% chance that if you are both carriers that the child would be a CARRIER, 25% chance that the child would be CF mutation FREE (not even a carrier) and25%chance that they would HAVE CFAs I understand it the most likely to carry CF are Caucasian. Anyone of European descent. I lost my first pregnancy, it may have been because of us both being carriers, but it may not have had anything to do with it. I hope your hubby isn't a carrier.ANDREA

 

[scarlett]

About 1/25 caucasians is a carrier. Get your husband checked outGood luck.~scarlett

 

[Dea]

Actually1 in every 20 people is a carrier

 

[anonymous]

I don't like those odds!!! GRRR I wish the test would come back!

 

[anonymous]

I am a carrier and a mother of a child with Cf. My husband has what is considered an unknown mutation. So, even if we had him tested before we had our son (8 years ago) he would have come back mutant free. There are much better test that can map out almost the whole gene (about 1000 possible mutations) as opposed to the 97 on the standard test. Obvously, research on how to get him a more complete mutation test.