Colomycin

[anonymous]

Do any of you guys agree that if you take Colomycin continuously with no break that your body might build up a resistance to it? My daughter has been on it for 5 months now.

Charlotte<img src="i/expressions/oxygen.gif" border="0">

 

[anonymous]

Do any of you guys agree that if you take Colomycin continuously with no break that your body might build up a resistance to it? My daughter has been on it for 5 months now.

Charlotte<img src="i/expressions/oxygen.gif" border="0">

 

[Faust]

If colymycin is the non generic version of collistin, then my doctor told me that your bacteria can't become resistant to it, atleast your pseudo anyways, due to how the drug interacts with it. I dunno though.

 

[Faust]

If colymycin is the non generic version of collistin, then my doctor told me that your bacteria can't become resistant to it, atleast your pseudo anyways, due to how the drug interacts with it. I dunno though.

 

[anonymous]

Think it is. My daughter got rid of PA on her cough swabs after 4 months. First diagnosed when she was 10 months old so had Cipro and Colomycin. Off it for 7 months, then back on it again. Been on it now since last October. Startin 2 worry a bit tho now cos she has been on it with no break?

 

[anonymous]

Think it is. My daughter got rid of PA on her cough swabs after 4 months. First diagnosed when she was 10 months old so had Cipro and Colomycin. Off it for 7 months, then back on it again. Been on it now since last October. Startin 2 worry a bit tho now cos she has been on it with no break?

 

[Faust]

<blockquote>Quote<br><hr><i>Originally posted by: <b>Anonymous</b></i><br>Think it is. My daughter got rid of PA on her cough swabs after 4 months. First diagnosed when she was 10 months old so had Cipro and Colomycin. Off it for 7 months, then back on it again. Been on it now since last October. Startin 2 worry a bit tho now cos she has been on it with no break?<hr></blockquote>


Well as far as adult cystics go, I generally recommend patients not take a preventative antibiotic drug full time (or really even part time) due to the very strong chance of resistance down the road, and then when you REALLY need those particular antibiotics, you are skar00d due to a high chance of resistance. Do they work? Yeah. Do they make you feel better in the present? Yeah. But at what potential cost down the road? Now that was discussing adult cystics and those type of drugs, but what about children? Some studies have shown as long as the child isn't colonized they can help eradicate pseudo in them. While that is nice and all and a great thing, what about them almost inevitably getting pseudo again down the road? Pseudo infection amongst CF's is that prevalent for a reason. The bacteria is a highly opportunistic microbe that gravitates towards diseased tissue and immunosuppresed individuals. Due to our constant, never ending hardcore inflammation immune response that we have, we will always be like a giant black hole to Pseudo, meaning if it gets damn near anywhere near us, it's almost guaranteed to be sucked in and start it's cycle of colonization all over again.


Unless you want to live in a bubble from birth all through life, meaning a 100% sterile environment with no human contact in any way, if you are CF, Pseudo infection is as close to guaranteed as you can get in this discussion. Roaches find food that you leave out, Pseudo finds CF lungs.

 

[Faust]

<blockquote>Quote<br><hr><i>Originally posted by: <b>Anonymous</b></i><br>Think it is. My daughter got rid of PA on her cough swabs after 4 months. First diagnosed when she was 10 months old so had Cipro and Colomycin. Off it for 7 months, then back on it again. Been on it now since last October. Startin 2 worry a bit tho now cos she has been on it with no break?<hr></blockquote>


Well as far as adult cystics go, I generally recommend patients not take a preventative antibiotic drug full time (or really even part time) due to the very strong chance of resistance down the road, and then when you REALLY need those particular antibiotics, you are skar00d due to a high chance of resistance. Do they work? Yeah. Do they make you feel better in the present? Yeah. But at what potential cost down the road? Now that was discussing adult cystics and those type of drugs, but what about children? Some studies have shown as long as the child isn't colonized they can help eradicate pseudo in them. While that is nice and all and a great thing, what about them almost inevitably getting pseudo again down the road? Pseudo infection amongst CF's is that prevalent for a reason. The bacteria is a highly opportunistic microbe that gravitates towards diseased tissue and immunosuppresed individuals. Due to our constant, never ending hardcore inflammation immune response that we have, we will always be like a giant black hole to Pseudo, meaning if it gets damn near anywhere near us, it's almost guaranteed to be sucked in and start it's cycle of colonization all over again.


Unless you want to live in a bubble from birth all through life, meaning a 100% sterile environment with no human contact in any way, if you are CF, Pseudo infection is as close to guaranteed as you can get in this discussion. Roaches find food that you leave out, Pseudo finds CF lungs.

 

[anonymous]

So you think it is ok as she is 2 years old being on a 'preventative' antibiotic?<img src="i/expressions/face-icon-small-confused.gif" border="0">

Charlotte

 

[anonymous]

So you think it is ok as she is 2 years old being on a 'preventative' antibiotic?<img src="i/expressions/face-icon-small-confused.gif" border="0">

Charlotte

 

[Faust]

<blockquote>Quote<br><hr><i>Originally posted by: <b>Anonymous</b></i><br>So you think it is ok as she is 2 years old being on a 'preventative' antibiotic?<img src="i/expressions/face-icon-small-confused.gif" border="0">



Charlotte<hr></blockquote>


Well i'm obviously not a doctor, any and all of my advice comes from the streets of hardknocks (being 35 with CF and knowing many others with CF throughout life). But judging from common logic, it comes down to risk vs reward. If collistin honestly has a special characteristic about it, where takiung it doesn't influence your childs Pseudo to become resistant, and her being so young, yeah i'd say it's the right way to go. Now let's say if it was TOBI or something similar antibiotic wise, I wouldnt have my child on it, knowing what I know now (and personally went through). While it's not a universal law that everyone who is on tobi for a long term period will develope a resistant strain of pseudo to it, in terms of betting, it's a pretty safe bet. You take the antibiotic and kill of a large portion of your bad flora. There will ALWAYS be some that survive, and pass on that mutated survivor vs tobi gene onto the next generation...Rinse and repeat that process many many times, and you eventually end up with a pure resistant strain. They recently found out that bacteria, were able to communicate with each other as long as either fluid or air was present to carry their form of communication (forgot all the details, but i did read it somewhere). So you could have bacteria in one part of the lung that was being killed off by some medicine, and at the same exact time, they could communicate to other bacteria nearby on how to protect themself from the substance. When I read that, it really freaked me out. Of course that is a very lay way to explain it, but that's the jist of it.

 

[Faust]

<blockquote>Quote<br><hr><i>Originally posted by: <b>Anonymous</b></i><br>So you think it is ok as she is 2 years old being on a 'preventative' antibiotic?<img src="i/expressions/face-icon-small-confused.gif" border="0">



Charlotte<hr></blockquote>


Well i'm obviously not a doctor, any and all of my advice comes from the streets of hardknocks (being 35 with CF and knowing many others with CF throughout life). But judging from common logic, it comes down to risk vs reward. If collistin honestly has a special characteristic about it, where takiung it doesn't influence your childs Pseudo to become resistant, and her being so young, yeah i'd say it's the right way to go. Now let's say if it was TOBI or something similar antibiotic wise, I wouldnt have my child on it, knowing what I know now (and personally went through). While it's not a universal law that everyone who is on tobi for a long term period will develope a resistant strain of pseudo to it, in terms of betting, it's a pretty safe bet. You take the antibiotic and kill of a large portion of your bad flora. There will ALWAYS be some that survive, and pass on that mutated survivor vs tobi gene onto the next generation...Rinse and repeat that process many many times, and you eventually end up with a pure resistant strain. They recently found out that bacteria, were able to communicate with each other as long as either fluid or air was present to carry their form of communication (forgot all the details, but i did read it somewhere). So you could have bacteria in one part of the lung that was being killed off by some medicine, and at the same exact time, they could communicate to other bacteria nearby on how to protect themself from the substance. When I read that, it really freaked me out. Of course that is a very lay way to explain it, but that's the jist of it.

 

[anonymous]

Freaks me out 2. Never mind. Thanks for your advice. Good Nite.

Charlotte

 

[anonymous]

Freaks me out 2. Never mind. Thanks for your advice. Good Nite.

Charlotte

 

[anonymous]

DS's doctor has all his patients on cephlexin (keflex) to prevent strep or staph -- one of the s bugs. And he's said that some people disagree with this. His view is that strep can destroy lung tissue in hours and that there are other classes of antibiotics that can be used down the road for other types of infection -- cipro, septra, vanco... Our doctor is one of those who believes in preventative antibiotics. We have another doctor who is local who is more reactive -- doesn't think we should be doing CPT with nebs yet, is horrified about the antibiotics. But we have more faith in the other doctor whose background is in infectious disease. Gotta go with who you're most comfortable with and what you're most comfortable with doing. Liza

 

[anonymous]

DS's doctor has all his patients on cephlexin (keflex) to prevent strep or staph -- one of the s bugs. And he's said that some people disagree with this. His view is that strep can destroy lung tissue in hours and that there are other classes of antibiotics that can be used down the road for other types of infection -- cipro, septra, vanco... Our doctor is one of those who believes in preventative antibiotics. We have another doctor who is local who is more reactive -- doesn't think we should be doing CPT with nebs yet, is horrified about the antibiotics. But we have more faith in the other doctor whose background is in infectious disease. Gotta go with who you're most comfortable with and what you're most comfortable with doing. Liza

 

[Faust]

<blockquote>Quote<br><hr><i>Originally posted by: <b>Anonymous</b></i><br>DS's doctor has all his patients on cephlexin (keflex) to prevent strep or staph -- one of the s bugs. And he's said that some people disagree with this. His view is that strep can destroy lung tissue in hours and that there are other classes of antibiotics that can be used down the road for other types of infection -- cipro, septra, vanco... Our doctor is one of those who believes in preventative antibiotics. We have another doctor who is local who is more reactive -- doesn't think we should be doing CPT with nebs yet, is horrified about the antibiotics. But we have more faith in the other doctor whose background is in infectious disease. Gotta go with who you're most comfortable with and what you're most comfortable with doing. Liza<hr></blockquote>


Yeah I mean it's all a personal view really. Nebs and CPT to me are 100% a necessity, where as I personally don't buy into the preventive antibiotic angle, though many others do. You also should look into how bad the colonization/infection is. As an example look at me, my last culture showed "very light" population of both staph aureus and pseudo. I feel great, and have very high PFT's. Does that necessitate me being on any form of antibiotic that could potentially lead to resistance? Not in my opinion. Now if I was real messed up with heavy count of their population in my lungs, then yeah, it's something to seriously consider. I'm just one of these people who if I fart crossways I don't take a pill for it, especially antibiotic. There are many normal people out there who get a little chesty or sniffly and immediately run to the doctor for an antibiotic, and they give it to them. Some of the most healthy people I know are people who refuse to use antibiotics unless it's very serious. I generally agree, unless I have something very freaky that can spiral out of control and kill me fast CF wise. My ladies dad is like that (refuses to use antibiotics), and he is rediculously healthy. It's all perspective, and risk vs reward in the end in my opinion. If you are in bad shape, use what's available.

 

[Faust]

<blockquote>Quote<br><hr><i>Originally posted by: <b>Anonymous</b></i><br>DS's doctor has all his patients on cephlexin (keflex) to prevent strep or staph -- one of the s bugs. And he's said that some people disagree with this. His view is that strep can destroy lung tissue in hours and that there are other classes of antibiotics that can be used down the road for other types of infection -- cipro, septra, vanco... Our doctor is one of those who believes in preventative antibiotics. We have another doctor who is local who is more reactive -- doesn't think we should be doing CPT with nebs yet, is horrified about the antibiotics. But we have more faith in the other doctor whose background is in infectious disease. Gotta go with who you're most comfortable with and what you're most comfortable with doing. Liza<hr></blockquote>


Yeah I mean it's all a personal view really. Nebs and CPT to me are 100% a necessity, where as I personally don't buy into the preventive antibiotic angle, though many others do. You also should look into how bad the colonization/infection is. As an example look at me, my last culture showed "very light" population of both staph aureus and pseudo. I feel great, and have very high PFT's. Does that necessitate me being on any form of antibiotic that could potentially lead to resistance? Not in my opinion. Now if I was real messed up with heavy count of their population in my lungs, then yeah, it's something to seriously consider. I'm just one of these people who if I fart crossways I don't take a pill for it, especially antibiotic. There are many normal people out there who get a little chesty or sniffly and immediately run to the doctor for an antibiotic, and they give it to them. Some of the most healthy people I know are people who refuse to use antibiotics unless it's very serious. I generally agree, unless I have something very freaky that can spiral out of control and kill me fast CF wise. My ladies dad is like that (refuses to use antibiotics), and he is rediculously healthy. It's all perspective, and risk vs reward in the end in my opinion. If you are in bad shape, use what's available.

 

[thelizardqueen]

I went for my checkup today and talked to my docs about preventative medications, and medicating when you really don't need to. Out of the 10 antibiotics I can take for Staph, Pseudo, etc - I'm only reistant to one antibiotic. My infections are all very sensitive to the 9 other antibiotics. The reason for this, is because I only go on meds when I've got something freaky going on. My docs never put me on medications just because. If I had a runny nose, I never went on antibiotics, if I was fine and didn't have an active chest infection - I didn't go on antibiotics. Because I don't go on meds unless I'm sick with an ACTIVE chest infection - I have 9 antibiotics that still do the job. My doc says this is very rare in CFers at my age because majority of CFer's are usually on oral and inhaled antibiotics just in case, along with tuneups that really aren't required.

 

[thelizardqueen]

I went for my checkup today and talked to my docs about preventative medications, and medicating when you really don't need to. Out of the 10 antibiotics I can take for Staph, Pseudo, etc - I'm only reistant to one antibiotic. My infections are all very sensitive to the 9 other antibiotics. The reason for this, is because I only go on meds when I've got something freaky going on. My docs never put me on medications just because. If I had a runny nose, I never went on antibiotics, if I was fine and didn't have an active chest infection - I didn't go on antibiotics. Because I don't go on meds unless I'm sick with an ACTIVE chest infection - I have 9 antibiotics that still do the job. My doc says this is very rare in CFers at my age because majority of CFer's are usually on oral and inhaled antibiotics just in case, along with tuneups that really aren't required.