First, he should be tested to see if he has any sperm in his ejaculation. This is a simple and non-invasive procedure. He has to ejaculate into a cup and take it to a lab for a semen analysis. That right there will let you know if he has CBAVD (congenital bilateral absense of the vas deferens-meaning NO tube that carries the sperm from the testicles to the ejaculation), or he might have an obstuction because as you probably know, those with CF have very thick secretions and it's usually not limited to just one place in the body. Based on those results you have a few options. You can have a testicular biopsy done on him which is usually done at a urologists office and from what we have heard is somewhat painful but patients are able to walk out of the clinic and need a day of "down time" that day and the day after. The testicular biopsy will show if you husband has any "viable" sperm. From there you can consider in-vetro. There is a newer form of invetro called ICSI (I believe it is spelled Intracytoplasmic sperm injection but you can find info online by just doing and invetro search) where they give the woman medication to stimulate her ovaries causing about 15-30 eggs to be produced. Then they do another testicular biopsy (or you can usually have the sperm frozen from the initial one) and retrieve sperm from the man. They fertilize the eggs by hand and allow the embryos to grow for three days in a dish. At that point they re-plant the fertilized embryos inside the womans body (my doctor told me usually 3-6 to help guarante a baby because they don't all survive) and wait for them to grow. If they implant in your uterus then guess what-You are pregnant. Some clinics also offer an option to freeze any extra embryos (the ones that are already fertilized) to use later. Usually it is a lot less expensive to un-freeze the embryos than it is to have the egg retrieval and testicular biopsy over again. I have been asking on the family section if any male with CF has had success with this procedure yet, and I recieved one reply that indicated a man in New Zeland who has CF has children, possibly by this method, but nothing more solid than that yet.
My husband will be seeing his urologist at the end of November for the testicular biopsy so I will let you know what our results are. If all is good and well and he has viable sperm, then we are put on a waiting list for an ICSI procedure. Depending on where you live and the clinic you go to it will run you anywhere from $10-18K.
Hope this helps,
Julie