I found this on another board and though that I would pass along this information.
"Dr. Felix Ratjen (from Germany, now director of the Toronto Hospital for Sick Children CF clinic) gave one of the medical presentations at our recent Ontario Provincial Association Meeting (a division of CCFF). One interesting item he mentioned was the discovery that CFTR is expressed in muscles! This is now being studied further and a special SMRI machine has being used in Toronto to measure muscle currents. There are abnormalities in the muscles of those with CF. There also is still a possibility that the abnormalities could be related to inflammation.
Very interestingly, though, using potential difference,it is noted that
chloride conductance improves with intensiveexercise! This implies that intensive exercise MAY cause chemical changesthat help to overcome the CFTR defect. Exercise improves health status most dramatically for sedentary females who begin exercise, more so than for sedentary males who begin exercise - again suggesting a chemical or hormonal effect. However, already active females and already active males have equal health status.
The effect of exercise on CFTR _expression may help explain why those with CF who do intensive exercise seem to do so much better health-wise. The benefits of exercise in a person with CF may be more far-reaching than the benefits of exercise in a non-CF person.
"Dr. Felix Ratjen (from Germany, now director of the Toronto Hospital for Sick Children CF clinic) gave one of the medical presentations at our recent Ontario Provincial Association Meeting (a division of CCFF). One interesting item he mentioned was the discovery that CFTR is expressed in muscles! This is now being studied further and a special SMRI machine has being used in Toronto to measure muscle currents. There are abnormalities in the muscles of those with CF. There also is still a possibility that the abnormalities could be related to inflammation.
Very interestingly, though, using potential difference,it is noted that
chloride conductance improves with intensiveexercise! This implies that intensive exercise MAY cause chemical changesthat help to overcome the CFTR defect. Exercise improves health status most dramatically for sedentary females who begin exercise, more so than for sedentary males who begin exercise - again suggesting a chemical or hormonal effect. However, already active females and already active males have equal health status.
The effect of exercise on CFTR _expression may help explain why those with CF who do intensive exercise seem to do so much better health-wise. The benefits of exercise in a person with CF may be more far-reaching than the benefits of exercise in a non-CF person.