My husband and i have been having the long conversation about having our biological kids. He has been tested through the ambry amplified and is not a carrier. This simplified things alot, but during the interval of when he was being tested we did discuss ivf with pgd and how we felt about it and this discussion has led to a new question.
I have a class 4 and a class 1 mutation. Most likely do to the Class 4 I am phenotypically mild -- I've actually gotten my FEV1's back up above the 100 mark during this period that we've been talking about kids (109 a week ago up from 94 a year ago!). I'm wondering if we can do PGD to select for my class 4 mutation? I figure if we're going to give a kid one of my crappy 7th chromosome, why not give them the better of the two?
With all I've read on the possibility of symptomatic carriers and the fact that the Class 4 will almost always express itself less severe phenotypically, this seems like a fair and good thing to do for our future child. What do you think?
Can they even do this with PGD? Or are they only able to detect a mutation and not which mutation it is?
Also, we're guaranteed to be giving our kid around a 4% chance that they will have to deal with dual carrier status with the person they marry. Hopefully by then there won't be any "unidentified mutations", but just on the slight chance that they are in the 4% that marry a cf carrier spouse and the .001% that their spouse have an unidentified mutation, having hte clas 4 mutation would lead to a much better result than having the class 1..
Obviously this is not something we are running into. We actually decided to start seeing a counselor to make sure that the hard questions that we're hesitant to ask get asked and this process has been great for us. I have the complete blessing of my CF team also. We just want to do the best that we can.
I know the arguments about "why even try to have your biological kid" and am definitely willing to entertain and think about them and would adopt in a heartbeat, but that's not the part of the discussion that we're having right now, so I'd appreciate it if I didn't get any slams for even debating this.
I have a class 4 and a class 1 mutation. Most likely do to the Class 4 I am phenotypically mild -- I've actually gotten my FEV1's back up above the 100 mark during this period that we've been talking about kids (109 a week ago up from 94 a year ago!). I'm wondering if we can do PGD to select for my class 4 mutation? I figure if we're going to give a kid one of my crappy 7th chromosome, why not give them the better of the two?
With all I've read on the possibility of symptomatic carriers and the fact that the Class 4 will almost always express itself less severe phenotypically, this seems like a fair and good thing to do for our future child. What do you think?
Can they even do this with PGD? Or are they only able to detect a mutation and not which mutation it is?
Also, we're guaranteed to be giving our kid around a 4% chance that they will have to deal with dual carrier status with the person they marry. Hopefully by then there won't be any "unidentified mutations", but just on the slight chance that they are in the 4% that marry a cf carrier spouse and the .001% that their spouse have an unidentified mutation, having hte clas 4 mutation would lead to a much better result than having the class 1..
Obviously this is not something we are running into. We actually decided to start seeing a counselor to make sure that the hard questions that we're hesitant to ask get asked and this process has been great for us. I have the complete blessing of my CF team also. We just want to do the best that we can.
I know the arguments about "why even try to have your biological kid" and am definitely willing to entertain and think about them and would adopt in a heartbeat, but that's not the part of the discussion that we're having right now, so I'd appreciate it if I didn't get any slams for even debating this.