Ahh yes. I'm a 20/f w/CF. I've been on Pulmozyme since it first came out. I think... 11 years ago? I think I was 9, I forget. Anyhow, I've been taking it once a day every day for 11-some-odd years now. I love it. I mean, obviously, it's a pain in the ass to do the stuff every single day, but it's been a huge huge help to me. If I skip a day (I take it at night), I can tell the very next morning when I wake up, and I pay for skipping it all day. I don't know exactly what it does for me, except that I know I feel much lower without it, and that I believe my PFTs are much better on it. Though a pain in the ass sometimes, I'd definitely be a Pulmozyme supporter. It's good stuff. Feel free to ask me further on it. I've literally been on it since damn near the day it was approved. My pulmonologist jumped at the chance the second it was available. Hope I was of help. -Emily