I've been doing my Xopenex, then my vest and Hypertonic Saline for 25 minutes, then waiting at least 15 min. (sometimes take a shower) and then do my Pulmozyme, but this is new- I was doing the Pulmozyme and then the HS, but I'm coughing less so far this way, and feeling clear <img src=""> .
I mainly do it this way because of time. If I'm really running behind, I'll do Xopenex when I start my vest.