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Who wants to be the viagra guinae pig?

E

Ender

New member
As i said in the abstract, viagra was shown to correct the cftr placement in the cell membrane.

Here's an article on this as well...

<b>Sildenafil (Viagra) corrects DeltaF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis.</b>
Dormer RL, Harris CM, Clark Z, Pereira MM, Doull IJ, Norez C, Becq F, McPherson MA.

Department of Medical Biochemistry and Immunology, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, UK. dormer@cardiff.ac.uk

BACKGROUND: Most patients with cystic fibrosis (CF) have a DeltaF508 mutation resulting in abnormal retention of mutant gene protein (DeltaF508-CFTR) within the cell. This study was undertaken to investigate DeltaF508-CFTR trafficking in native cells from patients with CF with the aim of discovering pharmacological agents that can move DeltaF508-CFTR to its correct location in the apical cell membrane. METHOD: Nasal epithelial cells were obtained by brushing from individuals with CF. CFTR location was determined using immunofluorescence and confocal imaging in untreated cells and cells treated with sildenafil. The effect of sildenafil treatment on CFTR chloride transport function was measured in CF15 cells using an iodide efflux assay. RESULTS: In most untreated CF cells DeltaF508-CFTR was mislocalised within the cell at a site close to the nucleus. Exposure of cells to sildenafil (2 hours at 37 degrees C) resulted in recruitment of DeltaF508-CFTR to the apical membrane and the appearance of chloride transport activity. Sildenafil also increased DeltaF508-CFTR trafficking in cells from individuals with CF with a single copy DeltaF508 (DeltaF508/4016ins) or with a newly described CF trafficking mutation (R1283M). CONCLUSIONS: The findings provide proof of principle for sildenafil as a DeltaF508-CFTR trafficking drug and give encouragement for future testing of sildenafil and related PDE5 inhibitors in patients with CF.

<b>SO</b> my question is, has anyone actually tried viagra and has anyone seen a difference? Or is anyone will to try it? I'm actually kinda curious lol!

Sean Davis, where are you?
 
B

blackchameleon

New member
how interesting!, i had jennifers hope post an ED thingy on here
 to see if any other guys with CF cannot "keep it
up". SO, i am talking to my doc in Sydney next thursday and im
hoping to get some viagra to see if mr floppy becomes mr big angry
pleasure machine again!!. wouldnt it just be bizzare if my CF was
eased because of such a frustrating problem!!. hmmm im not too sure
on contemplation which is worse , cystic fibrosis OR erectile
no-go-sis. i shall keep you informed of my predicament. the
blackchameleon is happy to be the guinea pig for this one.
 
J

JazzysMom

New member
So Viagra is good for something besides giving my hubby ANOTHER reason to chase me around the bedroom?! Well it wouldnt really help me, or would it LOL!
 
N

NoExcuses

New member
1. I just have a hard time believing that's true. If it was, why isn't every CF patient taking it? Reminds me of those info-mercials on TV. If you could just take a pill and lose weight, why wouldn't everyone be doing it? I'm extremely skeptical.


2. Pfizer (the maker of Viagra) has conducted Cystic Fibrosis trials before. Remember the zithromax clinical trial? Zithro is made by Pfizer as well. Granted the CFF did foot some of the bill. Who knows? Maybe Pfizer will jump on board again...
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>

1. I just have a hard time believing that's true. If it was, why isn't every CF patient taking it? Reminds me of those info-mercials on TV. If you could just take a pill and lose weight, why wouldn't everyone be doing it? I'm extremely skeptical.





2. Pfizer (the maker of Viagra) has conducted Cystic Fibrosis trials before. Remember the zithromax clinical trial? Zithro is made by Pfizer as well. Granted the CFF did foot some of the bill. Who knows? Maybe Pfizer will jump on board again...</end quote></div>

Um maybe because they just came up with the results, and they haven't had time to see if a long term treatment with viagra is safe and tolerable?

True or not, the research is there. What they do with that is another question
 
I

IG

Guest
Been there, seen that. Circa 03/2005:

<a target=_blank class=ftalternatingbarlinklarge href="http://forums.cysticfibrosis.com/messageview.cfm?catid=5&threadid=2525&highlight_key=y&keyword1=viagra
">http://forums.cysticfibrosis.c...key=y&keyword1=viagra
</a>
Old, though still interesting.
Please read Bambi's response to it (Seasprite).. I seem to remember her saying that she was a geneticist, or research scientist or something such as.

Thought I would let you know.
 
T

thelizardqueen

New member
Ok, I may be a girl, but I would be willing to try Viagra. For the sake of CF of course. LOL. Ever seen that episode of Sex and The City, where Samantha trys Viagra?
 
N

NoExcuses

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Ender</b></i>

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>



1. I just have a hard time believing that's true. If it was, why isn't every CF patient taking it? Reminds me of those info-mercials on TV. If you could just take a pill and lose weight, why wouldn't everyone be doing it? I'm extremely skeptical.











2. Pfizer (the maker of Viagra) has conducted Cystic Fibrosis trials before. Remember the zithromax clinical trial? Zithro is made by Pfizer as well. Granted the CFF did foot some of the bill. Who knows? Maybe Pfizer will jump on board again...</end quote></div>



Um maybe because they just came up with the results, and they haven't had time to see if a long term treatment with viagra is safe and tolerable?



True or not, the research is there. What they do with that is another question</end quote></div>

Um so are they doing phase II or phase III trials to test safety/tolerability?
 
S

Scarlett81

New member
Liz-This is very Sex and the City. lol.

I am very skeptical too. And we already know that Viagra is safe long term to people b/c its been here a while now. So, I don't know why they wouldn't be using it already on us. Of course, it could all be political garbage keeping it from us, you never know.

I appreciate your post however, and to answer your original question-H*ll NO would I ever try it. Sorry. Not a chance. Icky.

<img src="i/expressions/face-icon-small-disgusted.gif" border="0">
 
A

anonymous

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Scarlett81</b></i>

Liz-This is very Sex and the City. lol.



I am very skeptical too. And we already know that Viagra is safe long term to people b/c its been here a while now. So, I don't know why they wouldn't be using it already on us. Of course, it could all be political garbage keeping it from us, you never know.



I appreciate your post however, and to answer your original question-H*ll NO would I ever try it. Sorry. Not a chance. Icky.



<img src="i/expressions/face-icon-small-disgusted.gif" border="0"></end quote></div>

2 questions:


1. Why would you try it? What's icky about it?

2. What type of political stuff would be keeping Viagra from CF patients?

-Amy not signed in
 
J

JazzysMom

New member
I shouldnt reveal tis, but huggy has a script for Viagra. When I told him about this post he hinted I should try & see what happens. Hell No I said!
 
A

anonymous

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>JazzysMom</b></i>

So Viagra is good for something besides giving my hubby ANOTHER reason to chase me around the bedroom?! Well it wouldnt really help me, or would it LOL!</end quote></div>



you already revealed that here....
 
J

JazzysMom

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>anonymous</b></i>

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>JazzysMom</b></i>



So Viagra is good for something besides giving my hubby ANOTHER reason to chase me around the bedroom?! Well it wouldnt really help me, or would it LOL!</end quote></div>







you already revealed that here....</end quote></div>


ROFLMAO I didnt even remember responding. OH well!
 
A

anonymous

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>

1. I just have a hard time believing that's true. If it was, why isn't every CF patient taking it? Reminds me of those info-mercials on TV. If you could just take a pill and lose weight, why wouldn't everyone be doing it? I'm extremely skeptical.
</end quote></div>

How long has hypertonic saline been around? and CF patients are just starting to use it. I dont think it's impposible, but Its not something I would get my hopes up about.
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Ender</b></i>



<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>







1. I just have a hard time believing that's true. If it was, why isn't every CF patient taking it? Reminds me of those info-mercials on TV. If you could just take a pill and lose weight, why wouldn't everyone be doing it? I'm extremely skeptical.























2. Pfizer (the maker of Viagra) has conducted Cystic Fibrosis trials before. Remember the zithromax clinical trial? Zithro is made by Pfizer as well. Granted the CFF did foot some of the bill. Who knows? Maybe Pfizer will jump on board again...</end quote></div>







Um maybe because they just came up with the results, and they haven't had time to see if a long term treatment with viagra is safe and tolerable?







True or not, the research is there. What they do with that is another question</end quote></div>



Um so are they doing phase II or phase III trials to test safety/tolerability?</end quote></div>

You tell me.
 
J

JustDucky

New member
I haven't read alot about viagra in CF folks, but have read of its uses in pulmonary hypertension. Actually, it is being used in children with primary pulmonary hypertension (actually know a kiddie on the stuff). I have also heard of it being used in mountain clilmbers who develop issues with pulmonary edema. So....who knows? Hugs, Jenn <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
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