I just started open label about a month ago. I pretty much know that I had the placebo in the closed label (the real stuff tastes like s***, if yours doesn't you dont have the real thing hahaha). They said it might take a couple of months to start feeling better, but I have noticed that mucus is becoming easier and easier to bring up, and its almost like it is thinner. Like I said, I don't think I would have started to notice full effects yet, but I think the mucus thing is a good sign.