Hi Lauren! How do i update my signiture? is that in the profile? Also, yes, they have been talking about transplant more and more in the past year. Originally the mds told us that they typically start thinking transplant with a pft under 30. and with this last hospitalization they were talking about it alot more. They say of course, not to do it until you cannot get anymore out of your own lungs...but i don't know. it's a scary line to walk!! I think when he goes back to the md in a wk and a half, he is going to talk to them about starting the workup. they told him he can do the workup, but not do transplant until he's ready... just be a little ahead of the game. He has just been at 37-40 for so long, and been functioning so well, that i guess they have felt like he will be able to hold out a little longer, and if his drop had been more gradual, i agree. but when you are already that low a 10% drop is huge. also, i was wondering what all of these number things mean... like your g551d and df508? I am not familiar with these? pft is the only numbers we really talk about. is this like the genetic mutation or something? does knowing these numbers help in deciding treatment options? thanks for all the help!!