So, this happens to me all the time, but I thought maybe I just had a bad bunch of needles. I don't think that is the case anymore. Anyway, when I prime the needle on my Novopen and try to squirt out the two units, nothing comes out. So, I try again--still nothing. So, I try turning it to 10 units or more, and again nothing comes out. So I try a new needle. Repeat of above. At some point I find success, but this is ridiculous. Does this happen to anyone else? This doesn't happen every time, btw, but frequently.