Ir Med J. 2006 Nov-Dec;99(10):310-1. Links
Early onset of colonic adenocarcinoma associated with cystic fibrosis--a case report.
McKenna PB,
Mulcahy E,
Waldron D.
Department of Colorectal Surgery, Mid-Western Regional Hospital, Limerick. paul.mckenna@ul.ie
We report the case of the onset of colorectal adenocarcinoma occurring in an 18 year-old patient, suffering from Cystic Fibrosis. This represents a presentation of colon cancer at an earlier stage than previously reported. Despite this, <b>there is an established link between the two diseases although the pathogenesis is, </b>as yet, unknown. This early onset emphasizes yet another association with the disease and encourages clinicians to be aware of potentially disastrous complications.
PMID: 17274176 [PubMed - indexed for MEDLINE]
I believe with a high degree of certainty that it is a culmination of continuous inflammation, a heavier burden of oxidative stress (due to the nature of cf) AND lifestyle choices...most likely, the food we ingest. At the CF conference in 2000 (7 years ago) a study was released that due to dietary intake, cf pateints were only getting One fourth of the amount of vita c that is recommended by the USDA. Ok, we all know that those requirements are recommendations for healthy individuals...takes nothing into account for those of us with chronic illnesses. The cff is aware and is still not advocating better nutrition...7years ago....that is a long time ago.
Furthermore, recent studies have come out suggesting that cf people, while not experiencing raises in chloesterol, are experiencing the SAME amount of oxidative injury as healthy individuals from saturated fats. This is SIGNIFICANT because not only do you have your own little cascade of oxidation going on...everything unhealthy you are putting in your mouth is doing damage as well. What that means to you is double whammy on the stress to your body....how can your body protect itself when it has nothing to use as to fight off free radicals? All those little antioxidants are trying to keep up, but they can't because your system becomes over-burdened.
CFERS have a higher incedence of many illnesses....not just colon cancer....our incedence of lymphoma is higher as well.
Also, you have to look at the medicine that we require. For instance, the antibiotics. Everytime you take ivs, you are doing good stuff and causing damage. Take Tobra for instance. It is proven that it causes hearing loss...it is also PROVEN that those with low antioxidants in the blood suffer more hearing loss than others. It is also proven that hearing loss can be prevented by supplementing with antioxidants like gluathione, alpha lipoic acid and magnesium. Every time you take these drugs, you body is working its ass off to get the toxins out of your body before it can do damage. After years of high dose ivs, poor diet, and your oxidative burden, if you have not re-established a reserve, you are mosre likely to develop the more serious sid effects...hearing loss, kidney damage...you name it.
<b>Antioxidant enzyme levels inversely covary with hearing loss after amikacin treatment.</b>
Klemens JJ,
Meech RP,
Hughes LF,
Somani S,
Campbell KC.
Southern Illinois University School of Medicine, Springfield, IL, USA.
This study's purpose was to determine if a correlation exists between cochlear antioxidant activity changes and auditory function after induction of amino-glycoside (AG) ototoxicity. Two groups of five 250-350 g albino guinea pigs served as subjects. For 28 days, albino guinea pigs were administered either 200 mg/kg/day amikacin, or saline subcutaneously. Auditory brainstem response testing was performed prior to the first injection and again before sacrifice, 28 days later. Cochleae were harvested and superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase activities and malondialdehyde levels were measured. All antioxidant enzymes had significantly lower activity in the amikacin group (p < or = 0.05) than in the control group. The difference in cochlear antioxidant enzyme activity between groups inversely correlated significantly with the change in ABR thresholds. <b>The greatest correlation was for the high frequencies, which are most affected by aminoglycosides. This study demonstrates that antioxidant enzyme activity and amikacin-induced hearing loss significantly covary.
</b>PMID: 12859138 [PubMed - indexed for MEDLINE]