Does this happen to you when doing your tune ups?

[ladybug]

I usually run a fever when I'm on IV meds (usually start a few days after I've been on them)... I hallucinate and everything.

I've been told the same thing about the "bad toxins of pseudo. being released into the bloodstream". I guess it kinda makes sense. Still no fun though. But, I guess if you look at it like your body is getting BETTER and you had all that yuck pent up inside you, it looks a little more positive. <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I usually run a fever when I'm on IV meds (usually start a few days after I've been on them)... I hallucinate and everything.

I've been told the same thing about the "bad toxins of pseudo. being released into the bloodstream". I guess it kinda makes sense. Still no fun though. But, I guess if you look at it like your body is getting BETTER and you had all that yuck pent up inside you, it looks a little more positive. <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I usually run a fever when I'm on IV meds (usually start a few days after I've been on them)... I hallucinate and everything.

I've been told the same thing about the "bad toxins of pseudo. being released into the bloodstream". I guess it kinda makes sense. Still no fun though. But, I guess if you look at it like your body is getting BETTER and you had all that yuck pent up inside you, it looks a little more positive. <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I usually run a fever when I'm on IV meds (usually start a few days after I've been on them)... I hallucinate and everything.

I've been told the same thing about the "bad toxins of pseudo. being released into the bloodstream". I guess it kinda makes sense. Still no fun though. But, I guess if you look at it like your body is getting BETTER and you had all that yuck pent up inside you, it looks a little more positive. <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[ladybug]

I usually run a fever when I'm on IV meds (usually start a few days after I've been on them)... I hallucinate and everything.
<br />
<br />I've been told the same thing about the "bad toxins of pseudo. being released into the bloodstream". I guess it kinda makes sense. Still no fun though. But, I guess if you look at it like your body is getting BETTER and you had all that yuck pent up inside you, it looks a little more positive. <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[christyisnutz]

It sounds like serum sickness to me. If you are allergic or having serum sickness to cephalosporins, then you are most likely going to have the same reaction to penicillins. They are "cousins". I'd definitely get a consult with an allergist/immunologist about this.

 

[christyisnutz]

It sounds like serum sickness to me. If you are allergic or having serum sickness to cephalosporins, then you are most likely going to have the same reaction to penicillins. They are "cousins". I'd definitely get a consult with an allergist/immunologist about this.

 

[christyisnutz]

It sounds like serum sickness to me. If you are allergic or having serum sickness to cephalosporins, then you are most likely going to have the same reaction to penicillins. They are "cousins". I'd definitely get a consult with an allergist/immunologist about this.

 

[christyisnutz]

It sounds like serum sickness to me. If you are allergic or having serum sickness to cephalosporins, then you are most likely going to have the same reaction to penicillins. They are "cousins". I'd definitely get a consult with an allergist/immunologist about this.

 

[christyisnutz]

It sounds like serum sickness to me. If you are allergic or having serum sickness to cephalosporins, then you are most likely going to have the same reaction to penicillins. They are "cousins". I'd definitely get a consult with an allergist/immunologist about this.

 

[PedsNP2007]

Hi, I don't know why some of our children in the ICU react this way over others, but here is why you can actually get sicker after being initially treated with antibiotics.

Pseudomonas is a gram negative bacteria. The gram negative bacteria have very well "padded" coating - the outside is made up of several layers of membranes compared to gram positive bacteria. There is a complex lipopolysaccharide that has a lipid component that acts as an endotoxin (natural to the bacteria, bad for us). If released from the bacteria into our blood stream, it causes our body to mount a response and release a whole slew of agents into the blood stream. So you will actually feel cruddier initially as this happens. The bacteria don't produce and release endotoxin -- as it is part of the bacteria's cell membrane, the only way is when the bacteria are killed (hence, antibiotic therapy). Thus, bacteria killed = lots of endotoxin around.

We've used clindamycin on occasion in the past to help with this (there are studies showing this can help, but not for all cases by any means) -- some kids do worse after we start gram negative coverage... it's par for the course... most people don't progress to septic shock from this although it has been shown to happen. Usually you do supportive care (maintaining a good cardiac output by giving more fluids or starting bp meds, minimizing body's oxygen consumption, supporting respiratory if needed).

I hope this helped... it's a heck of a lot more complex especially when one gets into what agents are released when the endotoxins are in the bloodstream... I can't even remember all of the agents -- some good and some are bad.

I hope you feel better!! You are not alone with that process... it's just never really mentioned as it doesn't happen with every person with a gram negative infection who gets treated with antibiotics.

PM if you have any other questions.

Jenn
30 yo cf, cfrd, osteoporosis, critical care pediatric nurse practitioner

 

[PedsNP2007]

Hi, I don't know why some of our children in the ICU react this way over others, but here is why you can actually get sicker after being initially treated with antibiotics.

Pseudomonas is a gram negative bacteria. The gram negative bacteria have very well "padded" coating - the outside is made up of several layers of membranes compared to gram positive bacteria. There is a complex lipopolysaccharide that has a lipid component that acts as an endotoxin (natural to the bacteria, bad for us). If released from the bacteria into our blood stream, it causes our body to mount a response and release a whole slew of agents into the blood stream. So you will actually feel cruddier initially as this happens. The bacteria don't produce and release endotoxin -- as it is part of the bacteria's cell membrane, the only way is when the bacteria are killed (hence, antibiotic therapy). Thus, bacteria killed = lots of endotoxin around.

We've used clindamycin on occasion in the past to help with this (there are studies showing this can help, but not for all cases by any means) -- some kids do worse after we start gram negative coverage... it's par for the course... most people don't progress to septic shock from this although it has been shown to happen. Usually you do supportive care (maintaining a good cardiac output by giving more fluids or starting bp meds, minimizing body's oxygen consumption, supporting respiratory if needed).

I hope this helped... it's a heck of a lot more complex especially when one gets into what agents are released when the endotoxins are in the bloodstream... I can't even remember all of the agents -- some good and some are bad.

I hope you feel better!! You are not alone with that process... it's just never really mentioned as it doesn't happen with every person with a gram negative infection who gets treated with antibiotics.

PM if you have any other questions.

Jenn
30 yo cf, cfrd, osteoporosis, critical care pediatric nurse practitioner

 

[PedsNP2007]

Hi, I don't know why some of our children in the ICU react this way over others, but here is why you can actually get sicker after being initially treated with antibiotics.

Pseudomonas is a gram negative bacteria. The gram negative bacteria have very well "padded" coating - the outside is made up of several layers of membranes compared to gram positive bacteria. There is a complex lipopolysaccharide that has a lipid component that acts as an endotoxin (natural to the bacteria, bad for us). If released from the bacteria into our blood stream, it causes our body to mount a response and release a whole slew of agents into the blood stream. So you will actually feel cruddier initially as this happens. The bacteria don't produce and release endotoxin -- as it is part of the bacteria's cell membrane, the only way is when the bacteria are killed (hence, antibiotic therapy). Thus, bacteria killed = lots of endotoxin around.

We've used clindamycin on occasion in the past to help with this (there are studies showing this can help, but not for all cases by any means) -- some kids do worse after we start gram negative coverage... it's par for the course... most people don't progress to septic shock from this although it has been shown to happen. Usually you do supportive care (maintaining a good cardiac output by giving more fluids or starting bp meds, minimizing body's oxygen consumption, supporting respiratory if needed).

I hope this helped... it's a heck of a lot more complex especially when one gets into what agents are released when the endotoxins are in the bloodstream... I can't even remember all of the agents -- some good and some are bad.

I hope you feel better!! You are not alone with that process... it's just never really mentioned as it doesn't happen with every person with a gram negative infection who gets treated with antibiotics.

PM if you have any other questions.

Jenn
30 yo cf, cfrd, osteoporosis, critical care pediatric nurse practitioner

 

[PedsNP2007]

Hi, I don't know why some of our children in the ICU react this way over others, but here is why you can actually get sicker after being initially treated with antibiotics.

Pseudomonas is a gram negative bacteria. The gram negative bacteria have very well "padded" coating - the outside is made up of several layers of membranes compared to gram positive bacteria. There is a complex lipopolysaccharide that has a lipid component that acts as an endotoxin (natural to the bacteria, bad for us). If released from the bacteria into our blood stream, it causes our body to mount a response and release a whole slew of agents into the blood stream. So you will actually feel cruddier initially as this happens. The bacteria don't produce and release endotoxin -- as it is part of the bacteria's cell membrane, the only way is when the bacteria are killed (hence, antibiotic therapy). Thus, bacteria killed = lots of endotoxin around.

We've used clindamycin on occasion in the past to help with this (there are studies showing this can help, but not for all cases by any means) -- some kids do worse after we start gram negative coverage... it's par for the course... most people don't progress to septic shock from this although it has been shown to happen. Usually you do supportive care (maintaining a good cardiac output by giving more fluids or starting bp meds, minimizing body's oxygen consumption, supporting respiratory if needed).

I hope this helped... it's a heck of a lot more complex especially when one gets into what agents are released when the endotoxins are in the bloodstream... I can't even remember all of the agents -- some good and some are bad.

I hope you feel better!! You are not alone with that process... it's just never really mentioned as it doesn't happen with every person with a gram negative infection who gets treated with antibiotics.

PM if you have any other questions.

Jenn
30 yo cf, cfrd, osteoporosis, critical care pediatric nurse practitioner

 

[PedsNP2007]

Hi, I don't know why some of our children in the ICU react this way over others, but here is why you can actually get sicker after being initially treated with antibiotics.
<br />
<br />Pseudomonas is a gram negative bacteria. The gram negative bacteria have very well "padded" coating - the outside is made up of several layers of membranes compared to gram positive bacteria. There is a complex lipopolysaccharide that has a lipid component that acts as an endotoxin (natural to the bacteria, bad for us). If released from the bacteria into our blood stream, it causes our body to mount a response and release a whole slew of agents into the blood stream. So you will actually feel cruddier initially as this happens. The bacteria don't produce and release endotoxin -- as it is part of the bacteria's cell membrane, the only way is when the bacteria are killed (hence, antibiotic therapy). Thus, bacteria killed = lots of endotoxin around.
<br />
<br />We've used clindamycin on occasion in the past to help with this (there are studies showing this can help, but not for all cases by any means) -- some kids do worse after we start gram negative coverage... it's par for the course... most people don't progress to septic shock from this although it has been shown to happen. Usually you do supportive care (maintaining a good cardiac output by giving more fluids or starting bp meds, minimizing body's oxygen consumption, supporting respiratory if needed).
<br />
<br />I hope this helped... it's a heck of a lot more complex especially when one gets into what agents are released when the endotoxins are in the bloodstream... I can't even remember all of the agents -- some good and some are bad.
<br />
<br />I hope you feel better!! You are not alone with that process... it's just never really mentioned as it doesn't happen with every person with a gram negative infection who gets treated with antibiotics.
<br />
<br />PM if you have any other questions.
<br />
<br />Jenn
<br />30 yo cf, cfrd, osteoporosis, critical care pediatric nurse practitioner

 

[PedsNP2007]

I am going to ask my ICU attending tomorrow why some kids react more severely when the endotoxins are release compared to other similarly ill kids.

It's interesting how varied people's responses to antibiotics are.

Jenn

 

[PedsNP2007]

I am going to ask my ICU attending tomorrow why some kids react more severely when the endotoxins are release compared to other similarly ill kids.

It's interesting how varied people's responses to antibiotics are.

Jenn

 

[PedsNP2007]

I am going to ask my ICU attending tomorrow why some kids react more severely when the endotoxins are release compared to other similarly ill kids.

It's interesting how varied people's responses to antibiotics are.

Jenn

 

[PedsNP2007]

I am going to ask my ICU attending tomorrow why some kids react more severely when the endotoxins are release compared to other similarly ill kids.

It's interesting how varied people's responses to antibiotics are.

Jenn

 

[PedsNP2007]

I am going to ask my ICU attending tomorrow why some kids react more severely when the endotoxins are release compared to other similarly ill kids.
<br />
<br />It's interesting how varied people's responses to antibiotics are.
<br />
<br />Jenn