Successful decolonization of methicillin-resistant Staphylococcus aureus in paediatric patients with cystic fibrosis (CF) using a three-step protocol.
Macfarlane M, Leavy A, McCaughan J, Fair R, Reid AJ.
Northern Ireland Paediatric CF Centre, Royal Belfast Hospital for Sick Children, Royal Group of Hospitals, Belfast, Northern Ireland, UK.
Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as a bacterial pathogen in patients with cystic fibrosis (CF) although its clinical effects can be variable. The aim of this study was to evaluate the efficacy of a three-step decolonization protocol for MRSA (Belfast CF MRSA decolonization protocol). Of the 17 paediatric patients treated during the five years of the study, eight (47%) were successfully decolonized following one five-day course of oral rifampicin and fusidic acid. The success rate increased to 12 (71%) patients after a second five-day oral treatment course in the 11 patients who remained culture positive at the end of the first treatment cycle. In a further four patients, clearance was achieved with a course of intravenous teicoplanin, increasing the decolonization rate to 16 of 17 patients (94%). <b>These results compare favourably with other published studies and show that MRSA decolonization can be successful in a high proportion of paediatric CF patients</b>
This one too!!
J Cyst Fibros. 2005 Sep;4(3):205-7. Links
MRSA eradication in a health care worker with cystic fibrosis; re-emergence or re-infection?
Downey DG, Kidd TJ, Coulter C, Bell SC.
Adult Cystic Fibrosis Unit, Brisbane, QLD, Australia.
Methicillin-resistant Staphylocosis aureus (MRSA) is an emerging infection in patients with cystic fibrosis (CF). MRSA may be a management dilemma for healthcare workers (HCWs) with CF. <b>Eradication of MRSA with long-term rifampicin and fusidic acid can be achieved in patients with CF.</b> We describe a case of recurrent MRSA infection in a HCW with CF. Molecular typing of the MRSA isolates supported re-infection rather than re-emergence of an earlier MRSA infection. Infection control advice for HCWs with CF who acquire MRSA remains controversial.
Macfarlane M, Leavy A, McCaughan J, Fair R, Reid AJ.
Northern Ireland Paediatric CF Centre, Royal Belfast Hospital for Sick Children, Royal Group of Hospitals, Belfast, Northern Ireland, UK.
Methicillin-resistant Staphylococcus aureus (MRSA) is recognized as a bacterial pathogen in patients with cystic fibrosis (CF) although its clinical effects can be variable. The aim of this study was to evaluate the efficacy of a three-step decolonization protocol for MRSA (Belfast CF MRSA decolonization protocol). Of the 17 paediatric patients treated during the five years of the study, eight (47%) were successfully decolonized following one five-day course of oral rifampicin and fusidic acid. The success rate increased to 12 (71%) patients after a second five-day oral treatment course in the 11 patients who remained culture positive at the end of the first treatment cycle. In a further four patients, clearance was achieved with a course of intravenous teicoplanin, increasing the decolonization rate to 16 of 17 patients (94%). <b>These results compare favourably with other published studies and show that MRSA decolonization can be successful in a high proportion of paediatric CF patients</b>
This one too!!
J Cyst Fibros. 2005 Sep;4(3):205-7. Links
MRSA eradication in a health care worker with cystic fibrosis; re-emergence or re-infection?
Downey DG, Kidd TJ, Coulter C, Bell SC.
Adult Cystic Fibrosis Unit, Brisbane, QLD, Australia.
Methicillin-resistant Staphylocosis aureus (MRSA) is an emerging infection in patients with cystic fibrosis (CF). MRSA may be a management dilemma for healthcare workers (HCWs) with CF. <b>Eradication of MRSA with long-term rifampicin and fusidic acid can be achieved in patients with CF.</b> We describe a case of recurrent MRSA infection in a HCW with CF. Molecular typing of the MRSA isolates supported re-infection rather than re-emergence of an earlier MRSA infection. Infection control advice for HCWs with CF who acquire MRSA remains controversial.