Cystic Fibrosis Forum (EXP)
This is a sample guest message. Register a free account today to become a member! Once signed in, you'll be able to participate on this site by adding your own topics and posts, as well as connect with other members through your own private inbox!
inhaled levofloxacin
- Thread starter rvm1212
- Start date
Guys Phase III is over and they announced the results! http://finance.yahoo.com/news/aptalis-pharma-inc-announces-results-130000072.html
Here's what I gleaned from the article. Seems like good news to me, though not outrageously good--like PA obliteration. 
---Aeroquin was comparable or superior (aka not inferior) to inhaled tobramycin in terms of FEV1 at the end of each of three study periods (total of 168 days).
---Aeroquin patients ended with better lung function and lower PA in sputum when compared to the placebo patients, but Aeroquin did not lessen the time to first exacerbation.
---Aeroquin, inhaled tobramycin and placebo had similar tolerability and safety, though Aeroquin had increased metallic mouth-taste.
---Aeroquin was comparable or superior (aka not inferior) to inhaled tobramycin in terms of FEV1 at the end of each of three study periods (total of 168 days).
---Aeroquin patients ended with better lung function and lower PA in sputum when compared to the placebo patients, but Aeroquin did not lessen the time to first exacerbation.
---Aeroquin, inhaled tobramycin and placebo had similar tolerability and safety, though Aeroquin had increased metallic mouth-taste.
This is very good news! I can NOT AT ALL tolerate oral Levaquin,or any fluoroquinolones for that matter.
Levaquin is a very scary drug for me, makes me a nervous wreck, joint pain/cracking, terrible insomnia, don't feel my normal self-all the horrible symptoms of toxicity. It would be wonderful to inhale it ,- metallic taste is the least of my worries !
Levaquin is a very scary drug for me, makes me a nervous wreck, joint pain/cracking, terrible insomnia, don't feel my normal self-all the horrible symptoms of toxicity. It would be wonderful to inhale it ,- metallic taste is the least of my worries !
I'm like SoyaSauce, I have considered just getting worse in order to avoid Levaquin. I too find myself in extreme discomfort when on Levaquin, this use not to be an issue but I understand the toxicity levels are reached after awhile taking it. It also takes me time to recover from it, up to 3 months.
Any substitute to Levaquin is a good thing in my eyes!
Any substitute to Levaquin is a good thing in my eyes!