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John Hopkins Lab Scientists Tame Overactive CF Protien

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Prussian

New member
This has got to be the biggest discovery since they found the CF gene!

<a target=_blank class=ftalternatingbarlinklarge href="http://www.hopkinsmedicine.org/Press_releases/2006/06_29_06.html">http://www.hopkinsmedicine.org...ses/2006/06_29_06.html</a>
 
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Mockingbird

New member
"Studies show promise"

I've heard that many time before, and the promise was never kept. I don't mean to sound negative or skeptical or anything, I just believe in not counting the chickens before they hatch. If it turns into anything, then I will celebrate. For now, though, I'll just continue to live my life as before.
 
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ladybug

New member
I too am VERY cautiously optimistic about this! It sounds really really great if we get to benefit from it. This sort of language makes me nervous though...

<i>"The hope is that these findings will be used to design therapies and drugs that go beyond symptom management and actually restore normal cell function to prevent CF," says senior investigator Pamela Zeitlin, M.D., a pulmonologist at the Children's Center, although she warned that they are years from developing or testing such treatments in whole animals or people. A report on the work from scientists at the Children's Center and the University of Maryland appears in the June 23 issue of the Journal of Biological Chemistry.</i>

I never get too excited when they "warn" it may be years before its even studied. <img src="i/expressions/face-icon-small-sad.gif" border="0"> Some of us may not have years. I wish these things would move a lot faster. It is exciting news though and I really hope something comes of it sooner than later. <img src="i/expressions/face-icon-small-smile.gif" border="0">
 
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Scarlett81

New member
Well, thanks for sharing that-reading the article was fascinating.

It is very hard to not be jaded, though. As was said, we've all heard "this is promising" or "it will be years before this is given to patients."

I think its very sad that things like money and corporations and politics get in the way of us receiving these things. But we need to try to remember that there are thousands of dedicated sincere workers trying to get us what we need!

Let's hope.and yes-Hurry!
 
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NoExcuses

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>ladybug</b></i>

Some of us may not have years. I wish these things would move a lot faster. <img src="i/expressions/face-icon-small-smile.gif" border="0"></end quote></div>


You know what would make these things move faster? The demise of socialized medicine in Europe, Australia and Canada.

There is very little incentive to develop drugs in these countries because pharmaceutical companies cannot get a return on investment like they can here in the States.

Nothing is free in life - even if your government is paying for your meds, it comes at a price. And the price is on future development of medicatiions.

Imagine if we had the R&D that we have here in the States taking place in Europe? That would be double the effort to find new meds.

But as with anything, innovation and research and development are supressed when prices are regulated.

A great example is here in the STates with agriculture. Our government subsidises agri so there is no incentive to develop new and better technologies to make agri more efficient.

Granted this is an example of subsidies instead of price controls, but the theory is the same - the market serves to send signals to companies as to where to use their time and money.

More pharma companies might be more interested in devloping CF drugs if price controls were in place in Europe as well. The market would nearly double! What an incentive to develop new meds!!!

Winston Churchill had such great wisdom.....
 
E

Ender

New member
<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>amy</b></i>

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>ladybug</b></i>



Some of us may not have years. I wish these things would move a lot faster. <img src=""></end quote></div>





You know what would make these things move faster? The demise of socialized medicine in Europe, Australia and Canada.



There is very little incentive to develop drugs in these countries because pharmaceutical companies cannot get a return on investment like they can here in the States.


.....</end quote></div>

I don't get it, couldn't they just develop the drugs here and then sell them to you where the prices aren't regulated?

So the demise of socialized medicine is called healthcare?

Anyways, the article sounded amazing. Hopefully they can find a drug to inhibit the protein...relatively soon.

However, they also said that the inhibitors already used might work a little? I would consider something like this if i was pretty rough. What do you have to lose?
 
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sdelorenzo

Guest
Well I think the best thing in the article is the fact that one drug already being used to treat myeloma works to correct the cf defect. That is important because it is already approved by the FDA. If it does turn out that it works for those with cf, then it will be available much sooner than a drug that has not gone through all of those channels.
Sharon, mom of Sophia, 5 and Jack, 2 both with cf
 
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