I always take them with enzymes as i always take them with my breakfast and dinner, though i never really thought about it, that it was better to take them with enzymes. Thinking about it, is must be better. As A D E and K are vitamines we need because because they have something to do with fat that we can't absorbe (sorry don't know how to say that in english). So i does make sense to take them with enzymes. I'm not sure about vitamine B though, but since you have that all in one that comes in the package i guess hehe.
I have all different pills, AD, B, E and K. I think in a way that is better because they can give you more of one thing when one vitamine is low in your body. As too many can be dangerous too. When i was younger they tested my vitamine E when i was already on it but only 1 tablet ( i think 50mg) and it showed needed more, 4 tablets instead of 1.