I think Pulmozyme works best when it has time to sit in the lung and do its job. Doing HTS right after it seems counterproductive. You're basically coughing out the pulmozyme you just inhaled. Isn't better to use the HTS to get out as much junk as possible, then hit it with the pulmozyme? Then the pulmozyme has less mucus to work on and can be more effective. I think that's why there is some logic to Ronnie's doctors telling him to separate it out. This way the pulmozyme has time to work. It's the same logic as inhaled antibiotics - you want them to sit in the lung and do their work. My two cents.