Pregnant

dasjsmum · Aug 17, 2009

Sorry to disagree cfsue, but if you have cf, your child HAS to be a carrier, because they inherit a gene from you, and both your copies have the cf mutation.

Have a read through LouLou's post, what are your two mutations? Your daughter has to have inherited one of your genes eg:

I am a carrier (I think DF508), my spouse is a carrier (I think G551D).

We have three children who have cf and one who doesnt. The three that have it have the DF508 + G551D. My son wocf is not a carrier for DF508 (we know that much, because we have a post natal newborn screen for numerous diseases, and cf is one of them. The screen is taken on all newborns and came into place in 1981, and I assume they test for the DF508 gene in the blood sample, maybe they've widened that now).

I dont think he has been tested for G551D, if not, he could be a carrier of G551D. You daughter HAS to be a carrier of ONE of your genes, and since you have TWO copies, and they are both defective, she has to have one of them (I hope this makes sense?).

Have you had your daughter tested for both your mutations?

dasjsmum · Aug 17, 2009

Sorry to disagree cfsue, but if you have cf, your child HAS to be a carrier, because they inherit a gene from you, and both your copies have the cf mutation.

Have a read through LouLou's post, what are your two mutations? Your daughter has to have inherited one of your genes eg:

I am a carrier (I think DF508), my spouse is a carrier (I think G551D).

We have three children who have cf and one who doesnt. The three that have it have the DF508 + G551D. My son wocf is not a carrier for DF508 (we know that much, because we have a post natal newborn screen for numerous diseases, and cf is one of them. The screen is taken on all newborns and came into place in 1981, and I assume they test for the DF508 gene in the blood sample, maybe they've widened that now).

I dont think he has been tested for G551D, if not, he could be a carrier of G551D. You daughter HAS to be a carrier of ONE of your genes, and since you have TWO copies, and they are both defective, she has to have one of them (I hope this makes sense?).

Have you had your daughter tested for both your mutations?

dasjsmum · Aug 17, 2009

Sorry to disagree cfsue, but if you have cf, your child HAS to be a carrier, because they inherit a gene from you, and both your copies have the cf mutation.

Have a read through LouLou's post, what are your two mutations? Your daughter has to have inherited one of your genes eg:

I am a carrier (I think DF508), my spouse is a carrier (I think G551D).

We have three children who have cf and one who doesnt. The three that have it have the DF508 + G551D. My son wocf is not a carrier for DF508 (we know that much, because we have a post natal newborn screen for numerous diseases, and cf is one of them. The screen is taken on all newborns and came into place in 1981, and I assume they test for the DF508 gene in the blood sample, maybe they've widened that now).

I dont think he has been tested for G551D, if not, he could be a carrier of G551D. You daughter HAS to be a carrier of ONE of your genes, and since you have TWO copies, and they are both defective, she has to have one of them (I hope this makes sense?).

Have you had your daughter tested for both your mutations?

dasjsmum · Aug 17, 2009

Sorry to disagree cfsue, but if you have cf, your child HAS to be a carrier, because they inherit a gene from you, and both your copies have the cf mutation.

Have a read through LouLou's post, what are your two mutations? Your daughter has to have inherited one of your genes eg:

I am a carrier (I think DF508), my spouse is a carrier (I think G551D).

We have three children who have cf and one who doesnt. The three that have it have the DF508 + G551D. My son wocf is not a carrier for DF508 (we know that much, because we have a post natal newborn screen for numerous diseases, and cf is one of them. The screen is taken on all newborns and came into place in 1981, and I assume they test for the DF508 gene in the blood sample, maybe they've widened that now).

I dont think he has been tested for G551D, if not, he could be a carrier of G551D. You daughter HAS to be a carrier of ONE of your genes, and since you have TWO copies, and they are both defective, she has to have one of them (I hope this makes sense?).

Have you had your daughter tested for both your mutations?

dasjsmum · Aug 17, 2009

Sorry to disagree cfsue, but if you have cf, your child HAS to be a carrier, because they inherit a gene from you, and both your copies have the cf mutation.
<br />
<br />Have a read through LouLou's post, what are your two mutations? Your daughter has to have inherited one of your genes eg:
<br />
<br />I am a carrier (I think DF508), my spouse is a carrier (I think G551D).
<br />
<br />We have three children who have cf and one who doesnt. The three that have it have the DF508 + G551D. My son wocf is not a carrier for DF508 (we know that much, because we have a post natal newborn screen for numerous diseases, and cf is one of them. The screen is taken on all newborns and came into place in 1981, and I assume they test for the DF508 gene in the blood sample, maybe they've widened that now).
<br />
<br />I dont think he has been tested for G551D, if not, he could be a carrier of G551D. You daughter HAS to be a carrier of ONE of your genes, and since you have TWO copies, and they are both defective, she has to have one of them (I hope this makes sense?).
<br />
<br />Have you had your daughter tested for both your mutations?
<br />
<br />

julie · Aug 18, 2009

Actually Jo there is a condition that occurs when I child inherits 2 chromosomes from one parent, it's rare but it happens, and when it happens to be on the chromosome that the CF mutation is on (it's been so long since I've discussed this I've forgotten most of the important stuff, LOL), that child is not a carrier. Not sure if that is cfsue's case, but it could be.

julie · Aug 18, 2009

Actually Jo there is a condition that occurs when I child inherits 2 chromosomes from one parent, it's rare but it happens, and when it happens to be on the chromosome that the CF mutation is on (it's been so long since I've discussed this I've forgotten most of the important stuff, LOL), that child is not a carrier. Not sure if that is cfsue's case, but it could be.

julie · Aug 18, 2009

Actually Jo there is a condition that occurs when I child inherits 2 chromosomes from one parent, it's rare but it happens, and when it happens to be on the chromosome that the CF mutation is on (it's been so long since I've discussed this I've forgotten most of the important stuff, LOL), that child is not a carrier. Not sure if that is cfsue's case, but it could be.

julie · Aug 18, 2009

Actually Jo there is a condition that occurs when I child inherits 2 chromosomes from one parent, it's rare but it happens, and when it happens to be on the chromosome that the CF mutation is on (it's been so long since I've discussed this I've forgotten most of the important stuff, LOL), that child is not a carrier. Not sure if that is cfsue's case, but it could be.

julie · Aug 18, 2009

Actually Jo there is a condition that occurs when I child inherits 2 chromosomes from one parent, it's rare but it happens, and when it happens to be on the chromosome that the CF mutation is on (it's been so long since I've discussed this I've forgotten most of the important stuff, LOL), that child is not a carrier. Not sure if that is cfsue's case, but it could be.

dasjsmum · Aug 18, 2009