pseudomonas???

[MiddleAgedLady]

I'm 55 and have cultured pseudomonas since I was 15 years old. What you read is true that it can be found anywhere there is moisture; it even grows in your kitchen sink. There's no way to avoid it and since your daughter is so young and the Drs are on top of it, I agree with all the good advice you are getting here.

----------------------
age 55 with CF/diagnosed at 26, MRSA, CF arthralgia, osteoarthritis, connective tissue disease, fibromyalgia

 

[MiddleAgedLady]

I'm 55 and have cultured pseudomonas since I was 15 years old. What you read is true that it can be found anywhere there is moisture; it even grows in your kitchen sink. There's no way to avoid it and since your daughter is so young and the Drs are on top of it, I agree with all the good advice you are getting here.

----------------------
age 55 with CF/diagnosed at 26, MRSA, CF arthralgia, osteoarthritis, connective tissue disease, fibromyalgia

 

[MiddleAgedLady]

I'm 55 and have cultured pseudomonas since I was 15 years old. What you read is true that it can be found anywhere there is moisture; it even grows in your kitchen sink. There's no way to avoid it and since your daughter is so young and the Drs are on top of it, I agree with all the good advice you are getting here.

----------------------
age 55 with CF/diagnosed at 26, MRSA, CF arthralgia, osteoarthritis, connective tissue disease, fibromyalgia

 

[MiddleAgedLady]

I'm 55 and have cultured pseudomonas since I was 15 years old. What you read is true that it can be found anywhere there is moisture; it even grows in your kitchen sink. There's no way to avoid it and since your daughter is so young and the Drs are on top of it, I agree with all the good advice you are getting here.

----------------------
age 55 with CF/diagnosed at 26, MRSA, CF arthralgia, osteoarthritis, connective tissue disease, fibromyalgia

 

[MiddleAgedLady]

I'm 55 and have cultured pseudomonas since I was 15 years old. What you read is true that it can be found anywhere there is moisture; it even grows in your kitchen sink. There's no way to avoid it and since your daughter is so young and the Drs are on top of it, I agree with all the good advice you are getting here.
<br />
<br />----------------------
<br />age 55 with CF/diagnosed at 26, MRSA, CF arthralgia, osteoarthritis, connective tissue disease, fibromyalgia

 

[kfw1963]

I'm 46 and have cultured pseudo as long as I can remember. My last culture I was growing three different strains. All in all I am still very healthy so it is not always as bas as you read about.

 

[kfw1963]

I'm 46 and have cultured pseudo as long as I can remember. My last culture I was growing three different strains. All in all I am still very healthy so it is not always as bas as you read about.

 

[kfw1963]

I'm 46 and have cultured pseudo as long as I can remember. My last culture I was growing three different strains. All in all I am still very healthy so it is not always as bas as you read about.

 

[kfw1963]

I'm 46 and have cultured pseudo as long as I can remember. My last culture I was growing three different strains. All in all I am still very healthy so it is not always as bas as you read about.

 

[kfw1963]

I'm 46 and have cultured pseudo as long as I can remember. My last culture I was growing three different strains. All in all I am still very healthy so it is not always as bas as you read about.

 

[ymikhale]

one thing about pseudo is that when you child has it you start spending much more time doing treatments which leaves less time for everything else. That is what happened with my daughter (18 m old). So for me the question is is it worth sacrificing the play in the dirt to be able to spend more time doing other things than nebulizers and the answer was yes. I don't keep my daughter in the bubble but i try to be a little more cautious and don't take unnecessary risks. so i would let her play outside but not just after it rained and i don't think it makes her less happy.
but again that is just my two cents

 

[ymikhale]

one thing about pseudo is that when you child has it you start spending much more time doing treatments which leaves less time for everything else. That is what happened with my daughter (18 m old). So for me the question is is it worth sacrificing the play in the dirt to be able to spend more time doing other things than nebulizers and the answer was yes. I don't keep my daughter in the bubble but i try to be a little more cautious and don't take unnecessary risks. so i would let her play outside but not just after it rained and i don't think it makes her less happy.
but again that is just my two cents

 

[ymikhale]

one thing about pseudo is that when you child has it you start spending much more time doing treatments which leaves less time for everything else. That is what happened with my daughter (18 m old). So for me the question is is it worth sacrificing the play in the dirt to be able to spend more time doing other things than nebulizers and the answer was yes. I don't keep my daughter in the bubble but i try to be a little more cautious and don't take unnecessary risks. so i would let her play outside but not just after it rained and i don't think it makes her less happy.
but again that is just my two cents

 

[ymikhale]

one thing about pseudo is that when you child has it you start spending much more time doing treatments which leaves less time for everything else. That is what happened with my daughter (18 m old). So for me the question is is it worth sacrificing the play in the dirt to be able to spend more time doing other things than nebulizers and the answer was yes. I don't keep my daughter in the bubble but i try to be a little more cautious and don't take unnecessary risks. so i would let her play outside but not just after it rained and i don't think it makes her less happy.
but again that is just my two cents

 

[ymikhale]

one thing about pseudo is that when you child has it you start spending much more time doing treatments which leaves less time for everything else. That is what happened with my daughter (18 m old). So for me the question is is it worth sacrificing the play in the dirt to be able to spend more time doing other things than nebulizers and the answer was yes. I don't keep my daughter in the bubble but i try to be a little more cautious and don't take unnecessary risks. so i would let her play outside but not just after it rained and i don't think it makes her less happy.
<br />but again that is just my two cents

 

[MicheleGazelle]

<a target=_blank class=ftalternatingbarlinklarge href="http://www.pubmedcentral.nih.gov/picrender.fcgi?doi=10.1172/JCI31499&blobtype=pdf">Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A - induced cytotoxicity</a>
Introductory paragraph to this PDF file:<div class="FTQUOTE"><begin quote>Progressive pulmonary disease and infections with Pseudomonas aeruginosa remain an intractable problem in cystic fibrosis (CF). At the cellular level, CF is characterized by organellar hyperacidification, which results in altered protein and lipid glycosylation. Altered pH of the trans-Golgi network (TGN) may further disrupt the protein processing and packaging that occurs in this organelle. Here we measured activity of the major TGN endoprotease furin and demonstrated a marked upregulation in human CF cells. Increased furin activity was linked to elevated production in CF of the immunosuppressive and tissue remodeling cytokine TGF-? and its downstream effects, including macrophage deactivation and augmented collagen secretion by epithelial cells. As furin is responsible for the proteolytic processing of a range of endogenous and exogenous substrates including growth factors and bacterial toxins, we determined that elevated furin-dependent activation of exotoxin A caused increased cell death in CF respiratory epithelial cells compared with genetically matched CF transmembrane conductance regulator - corrected cells. Thus elevated furin levels in CF respiratory epithelial cells contributes to bacterial toxin - induced cell death, fibrosis, and local immunosuppression. These data suggest that the use of furin inhibitors may represent a strategy for pharmacotherapy in CF.</end quote></div>

My read on this research article: Getting excess acidity under control helps fight PA. My opinion: Getting excess acidity under control is generally a good idea for anyone and very helpful for people with CF, who tend to be way too acid.

 

[MicheleGazelle]

<a target=_blank class=ftalternatingbarlinklarge href="http://www.pubmedcentral.nih.gov/picrender.fcgi?doi=10.1172/JCI31499&blobtype=pdf">Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A - induced cytotoxicity</a>
Introductory paragraph to this PDF file:<div class="FTQUOTE"><begin quote>Progressive pulmonary disease and infections with Pseudomonas aeruginosa remain an intractable problem in cystic fibrosis (CF). At the cellular level, CF is characterized by organellar hyperacidification, which results in altered protein and lipid glycosylation. Altered pH of the trans-Golgi network (TGN) may further disrupt the protein processing and packaging that occurs in this organelle. Here we measured activity of the major TGN endoprotease furin and demonstrated a marked upregulation in human CF cells. Increased furin activity was linked to elevated production in CF of the immunosuppressive and tissue remodeling cytokine TGF-? and its downstream effects, including macrophage deactivation and augmented collagen secretion by epithelial cells. As furin is responsible for the proteolytic processing of a range of endogenous and exogenous substrates including growth factors and bacterial toxins, we determined that elevated furin-dependent activation of exotoxin A caused increased cell death in CF respiratory epithelial cells compared with genetically matched CF transmembrane conductance regulator - corrected cells. Thus elevated furin levels in CF respiratory epithelial cells contributes to bacterial toxin - induced cell death, fibrosis, and local immunosuppression. These data suggest that the use of furin inhibitors may represent a strategy for pharmacotherapy in CF.</end quote></div>

My read on this research article: Getting excess acidity under control helps fight PA. My opinion: Getting excess acidity under control is generally a good idea for anyone and very helpful for people with CF, who tend to be way too acid.

 

[MicheleGazelle]

<a target=_blank class=ftalternatingbarlinklarge href="http://www.pubmedcentral.nih.gov/picrender.fcgi?doi=10.1172/JCI31499&blobtype=pdf">Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A - induced cytotoxicity</a>
Introductory paragraph to this PDF file:<div class="FTQUOTE"><begin quote>Progressive pulmonary disease and infections with Pseudomonas aeruginosa remain an intractable problem in cystic fibrosis (CF). At the cellular level, CF is characterized by organellar hyperacidification, which results in altered protein and lipid glycosylation. Altered pH of the trans-Golgi network (TGN) may further disrupt the protein processing and packaging that occurs in this organelle. Here we measured activity of the major TGN endoprotease furin and demonstrated a marked upregulation in human CF cells. Increased furin activity was linked to elevated production in CF of the immunosuppressive and tissue remodeling cytokine TGF-? and its downstream effects, including macrophage deactivation and augmented collagen secretion by epithelial cells. As furin is responsible for the proteolytic processing of a range of endogenous and exogenous substrates including growth factors and bacterial toxins, we determined that elevated furin-dependent activation of exotoxin A caused increased cell death in CF respiratory epithelial cells compared with genetically matched CF transmembrane conductance regulator - corrected cells. Thus elevated furin levels in CF respiratory epithelial cells contributes to bacterial toxin - induced cell death, fibrosis, and local immunosuppression. These data suggest that the use of furin inhibitors may represent a strategy for pharmacotherapy in CF.</end quote></div>

My read on this research article: Getting excess acidity under control helps fight PA. My opinion: Getting excess acidity under control is generally a good idea for anyone and very helpful for people with CF, who tend to be way too acid.

 

[MicheleGazelle]

<a target=_blank class=ftalternatingbarlinklarge href="http://www.pubmedcentral.nih.gov/picrender.fcgi?doi=10.1172/JCI31499&blobtype=pdf">Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A - induced cytotoxicity</a>
Introductory paragraph to this PDF file:<div class="FTQUOTE"><begin quote>Progressive pulmonary disease and infections with Pseudomonas aeruginosa remain an intractable problem in cystic fibrosis (CF). At the cellular level, CF is characterized by organellar hyperacidification, which results in altered protein and lipid glycosylation. Altered pH of the trans-Golgi network (TGN) may further disrupt the protein processing and packaging that occurs in this organelle. Here we measured activity of the major TGN endoprotease furin and demonstrated a marked upregulation in human CF cells. Increased furin activity was linked to elevated production in CF of the immunosuppressive and tissue remodeling cytokine TGF-? and its downstream effects, including macrophage deactivation and augmented collagen secretion by epithelial cells. As furin is responsible for the proteolytic processing of a range of endogenous and exogenous substrates including growth factors and bacterial toxins, we determined that elevated furin-dependent activation of exotoxin A caused increased cell death in CF respiratory epithelial cells compared with genetically matched CF transmembrane conductance regulator - corrected cells. Thus elevated furin levels in CF respiratory epithelial cells contributes to bacterial toxin - induced cell death, fibrosis, and local immunosuppression. These data suggest that the use of furin inhibitors may represent a strategy for pharmacotherapy in CF.</end quote>

My read on this research article: Getting excess acidity under control helps fight PA. My opinion: Getting excess acidity under control is generally a good idea for anyone and very helpful for people with CF, who tend to be way too acid.

 

[MicheleGazelle]

<a target=_blank class=ftalternatingbarlinklarge href="http://www.pubmedcentral.nih.gov/picrender.fcgi?doi=10.1172/JCI31499&blobtype=pdf">Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A - induced cytotoxicity</a>
<br />Introductory paragraph to this PDF file:<div class="FTQUOTE"><begin quote>Progressive pulmonary disease and infections with Pseudomonas aeruginosa remain an intractable problem in cystic fibrosis (CF). At the cellular level, CF is characterized by organellar hyperacidification, which results in altered protein and lipid glycosylation. Altered pH of the trans-Golgi network (TGN) may further disrupt the protein processing and packaging that occurs in this organelle. Here we measured activity of the major TGN endoprotease furin and demonstrated a marked upregulation in human CF cells. Increased furin activity was linked to elevated production in CF of the immunosuppressive and tissue remodeling cytokine TGF-? and its downstream effects, including macrophage deactivation and augmented collagen secretion by epithelial cells. As furin is responsible for the proteolytic processing of a range of endogenous and exogenous substrates including growth factors and bacterial toxins, we determined that elevated furin-dependent activation of exotoxin A caused increased cell death in CF respiratory epithelial cells compared with genetically matched CF transmembrane conductance regulator - corrected cells. Thus elevated furin levels in CF respiratory epithelial cells contributes to bacterial toxin - induced cell death, fibrosis, and local immunosuppression. These data suggest that the use of furin inhibitors may represent a strategy for pharmacotherapy in CF.</end quote>
<br />
<br />My read on this research article: Getting excess acidity under control helps fight PA. My opinion: Getting excess acidity under control is generally a good idea for anyone and very helpful for people with CF, who tend to be way too acid.