I generally feel like an entire truck ran over me, not really localized pain but all over pain, cramping sensation. I have spastic muscles as it is but it gets much worse with Zosyn. I also find that my electrolytes get really whacked out too not to mention my kidneys hating it. The docs usually give me a running IV to keep me well hydrated and my kidneys flushed when I am on Zosyn. I hope that you feel better soon Mel...as always, I am thinking of you. Hopefully that prandin does its job for your CFRD...Initially I was on Prandin but eventually switched to Lantus insulin because my sugars were all over the place. Hugs to you my friend, Jenn <img src="i/expressions/heart.gif" border="0">