Questions about GSH useage

[Faust]

Well maybe i'm out of order, but it seems noone ever really frequents the supplement forum, so here goes:

I have been using the theranaturals reduced L-Glutathione plus sodium bicarbonate supplement for about 4 days now. I have emailed a few of the doctors involved with it's study, and even talked to the company themselves about what they feel potential doseage is for a 200 lb CF adult male. So far none of my emails have been answered, and the guy on the phone just recommended to start low and work my way up. Well that's great, but still doesn't answer my dosing questions.

I said skr00 it and i'm doing two of the 200mg capsules in the morning in distilled water, and then again (same doseage) at night before bed. Doing it three times a day is out of the question due to me working soon and such, so if I currently need much more doseage wise, i'd have to work within two dosing periods (morning and night). I looked at one of the dosing formulas by one of the doctors, and maybe it's been a while since i've messed with math, but to me it looked like it worked out to 1400mg a day? Well considering the capsules are 200mg each, that would be 3 and 1/2 pills dissolved per session. Each bottle costs 35 bucks, and i'm already spending good money on other supplements. So my question to you guys is, does anyone know how much I should be taking? I don't care about sensitivity, so far 400mg doesn't bother me at all, probably due to me doing oregano oil for a long time now. I just don't feel any real difference now on the GSH as opposed to before, even though it has just been 4 or 5 days. I want to use the optimum recommended dose, but I also don't want to be going through the stuff so I have to buy 3 cups a month or something.

So anyone like Tom or anyone else know how much I should neb if i'm doing the treatments twice a day, and I weigh around 200lbs? I'll email naked pics of my sister to whoever comes through on this <img src="i/expressions/face-icon-small-smile.gif" border="0">

 

[Faust]

BTW I also posted it here because it might be forever and then some before anyone responds to this in the supplement forum, and I don't want to waste a ton of GSH by not doseing properly in the meantime.

 

[EnergyGal]

hi Sean

First I might add that if you would write in the supplement section many people will read your posts. IF you look there many people go and visit. look at the numbers.

I think the folks involved with the GSH study tell you to take way too much and the GSH can become toxic. It happened to me and I only took five hundred mg. or less per day

I am in a different situation but a close friend who is a nutritionist told me he feels many cf patients are over doing it and will not see the results. When you take a very large amount of one amino acid it off sets the other chains of aminos in the body. The same goes for B supplements. Take one large dose for a long time of Biotin for example you will off set the other B's.

There is always a balancing act with our bodies on all levels and I am sure you know that. From reading all your posts, I think you are a very intelligent person and you will figure what is right for you. I do not think More is Better. If you start to feel great then stick with what works. Do not upset the apple cart.

Someone from the GSH study once told me that some folks with cf might see elevated liver enzymes. How good is that?

I think Glutathione is an excellent supplement but how much? I have no clue but certainly not what is told.

I love muscle testing to figure out what I need. It is not an exact science but it does not leave you sitting in the dark. There are many books on this technique that you can learn yourself

good luck

 

[Faust]

Well I take 1800mg of NAC daily, and I have heard from many sources that NAC helps to increase your bodies natural glutathione production, but just taking either glutathione or NAC orally doesn't affect the glutathione present in the lungs/airways due to it not being able to travel between cells. So in order to get the benefit from glutathione in my lungs, I need to neb it. I'm doing a little under 800mg daily neb wise (due to the added sodium bicarbonate not being a full 200 mg of glutathione). Just curious if i'm in the right ballpark. I know doseage is different for all things depending on weight, and though i'm not huge, i'm not the typical CF male weight, so curious what I should be taking. The formula i saw previously (if I did it right), looked like 1400mg per day, and that seems like a ton of GSH, not considering how expensive that will be.

 

[EnergyGal]

If you are just nebbing gsh I would not take that much. Sounds too much to me. I saw what happend to my lungs by taking this into my sinuses. I cannot say for sure that gsh caused my problem but it was way too coincidental.

Since you are taking OO, overdoing things would not be cool. Have you thought about cycling on and off of GSh like using this Mon, wed, fri., Sun. and doing OO Tues Thurs Sat. I think this will give your body a break. You do not want to take too much. I do not remember how you were taking your inhalation alternatives but if you were doing it this all the better.

Besides nac, Vit c helps the uptake of Glutathione. I love asparagus and that is loaded with gsh

Have fun experimenting but try not to cause an explosion lol

I

 

[Faust]

<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>Risa</b></i>

If you are just nebbing gsh I would not take that much. Sounds too much to me. I saw what happend to my lungs by taking this into my sinuses. I cannot say for sure that gsh caused my problem but it was way too coincidental.



Since you are taking OO, overdoing things would not be cool. Have you thought about cycling on and off of GSh like using this Mon, wed, fri., Sun. and doing OO Tues Thurs Sat. I think this will give your body a break. You do not want to take too much. I do not remember how you were taking your inhalation alternatives but if you were doing it this all the better.



Besides nac, Vit c helps the uptake of Glutathione. I love asparagus and that is loaded with gsh



Have fun experimenting but try not to cause an explosion lol



I</end quote></div>


Ever watch the old Super Dave Osbourne episodes on the old Showtime? He aint got s**t on me woman! <img src="i/expressions/face-icon-small-smile.gif" border="0">

I loved those skits.

But yeah I agree. I think my prob is that CF aside, i'm so damn healthy, the rest of my body is as close to a normal person (non CF) as you can get without being fully non CF, so my body can take a pounding chemical wise and not revolt, and if it does it takes a very long time.

I have always been extremely resistant to chemicals, be them pain killers, sleeping pills, alcohol, whatever. What normally can send someone onto their back and asleep, it can easily take 4x or greater doseage for me to even feel any effects.

 

[EnergyGal]

you know your body and you know your pockets.

off topic now that I got your attention. I was doing a search on an old article that I was in and I entered my first name and the title of the article and out came something from Start Trek. This is hilarious to me.

Here it is:
CAPTAIN'S HOLIDAY
Producers: Ira Steven Behr, Hans Beimler and Richard Manning
Director: Chip Chalmers
Writer: Ira Steven Behr
Cast: Jennifer Hetrick (Vash), Michael Grodenchik (Sovak), Karen Landry (Ajur), Michael Champion (Boratus), Deirdre Imershein (Joval)
Picard is talked into taking a vacation on <b>Risa,</b> a pleasure planet. When he arrives, he bumps into a women who, pursued by a Ferengi, grabs him and kisses him as if they were old friends. They later meet again and, after introductions, Picard discovers that she is out to find the location of a device brought from the future. The Ferengi also wants the device or the disk that the woman, Vash, has that reveals the location of the device. Meanwhile, two security agents from the future confront Picard and tell him that he is destined to find the device and they have come back in time to retrieve it from him. Vash and Picard team up to find he device and thwart the Ferengi but, Picard hopes to turn it over to the security agents.

 

[EnergyGal]

Now i can tell people I have really been spaced out. After all the pain meds that I got this time after my transplant, i bet everyone i know would agree lol

 

[Faust]

Or you could say "My body has had Capt Picard on it"...I like that better <img src="i/expressions/face-icon-small-smile.gif" border="0">

 

[Tom]

Please take this for all that its worth (which may be nothing).

We started low and slowly increased the dosage to where we are now which is below the recommeded dosage for his weight. We have not increased his dosage because we don't see the need to at this point. He never coughs or has mucous that he brings up.

The inhaled GSH is helping his lungs to stay the way they are. He started inhaling GSH right after he finished tobi. He cultured positive for a light growth or PA and was put on tobi for a month. At that point he was coughing and sounded junky. Once we started the inhaled GSH, the cough disappeared and his lungs sounded clear. Also, the PA has not returned (probably because of the tobi).

The oral GSH is helping his digestion. His stools have become better over a period of months. His enzyme dosage was reduced because with the GSH he was becoming somewhat constipated. The reduction in enzymes relieved this and did not affect his weight gain. He actually has gained the most weight since he started GSH. Now, this was not an overnight thing.

Sean,

I think that you can remain at the dosage and schedule that you have started. Although the docs who did the study would not recommend that you start off with this high of a dose. You, however, know your body best.

Since you have such high PFTs and have clear lungs at the moment, I don't know if you will notice anything from the GSH. The main thing about nebbing GSH is that it can protect the lungs from further damage. There are also long term studies going on regarding GSHs antioxidant affects in the lungs.

I see GSH like a vitamin for the lungs. You don't see immediate results. It is a long term thing.

I have not seen any literature about GSH toxicity. In fact, serveral toxicity reports show that GSH is not toxic in large doses. Risa, I am curious about your knowledge of GSH toxicity. What experience did you have? What were you culturing and what was your lung function at the time you were taking it?

Sean, I am concerned about how much NAC you are taking. NAC can definately be toxic to your liver although I don't what dosage is too high. To protect itself, the liver processes the cysteine in NAC into a more stable less toxic form - GSH.
You may want to think about reducing your dosage of NAC - just an idea.

Just to let you know, many people experiment with what suites them best schedule wise. Most people do one or two inhaled treatments and then supplement the rest with oral GSH. In your case, you would not need to supplement with oral GSH because of the NAC.

For a 200lb male the dosage would be 6000 mg or 6 grams per day. That is a lot. I think that you can benefit from the amount that you are doing right now.

Who did you try to contact?

OK... where are the pics!<img src="i/expressions/face-icon-small-happy.gif" border="0"> Just kidding...

Tom

 

[EnergyGal]

That is wonderful Tom that your Son is doing so well on gsh

Sean I like your saying better.

 

[Scarlett81]

Hi SD-

Well I take it orally so, and I weigh only 125 lbs so, I can't help u with that. But, I do take NAC supplementally. And taking Vit C while you take the Glut and NAC helps. I also take it with my ADEK b/c (as u probably know), Glut is VERY hard to absorb, esp for people with CF. I think it's like only 40 % we actually absorb. (my doc told me that-and if I remember the absorption may have been even smaller) That's why it's almost better to just take the building blocks of Glut and let your body build the actual Glut itself.
I noticed great results when I started Glut. I take 300mg with 50mg of NAC, 2x a day. And when I started taking the NAC I noticed greater results. Now I take both doses with my ADEK, to help absorb it all. Vit is also a building block of it, so I take that with it too.
I think in general, amino acids and antioxidants are the key. They are what reduce inflammation, take care of cell oxygen transfer (which we lack), and repair lung damage. A GREAT book I reccomend is "Prescription for Nutritional Healing-3rd edition" by Phyllis Balch. You can get it at Borders or Amazon. It is a supplement encyclopedia and explains deeper the working of aminos and antioxidants, and all natural supplements and remedies. But I like it cause it doesn't just describe them-it explains how all herbs and supplements work on a cellular level.

 

[Faust]

wow nebbing 6000mg of GSH a day? That would be insane. I would have to mortgage our house to be able to afford that lol.

 

[anonymous]

Christian,
Just curious, You said you were taking 50mg of NAC, I was just wondering if you meant 500mg or if you are taking in fact 50?

 

[Scarlett81]

Sorry I should have clarified that. The Glut supplememnt I have has 50mg's in it. But, I do take an additional 300mg's in the middle of the day.

I'm not a "multi" person. I take all my supplements separate. (meaning other than my ADEK, I take all my B vits, vit C, ect individually.) That way if I want to increase just Vit c, for example, I can and I don't have to take 2 multis.