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Stem cell treatments for CF?

I

IG

Guest
Afaik it's not going on with CF patients. I think CF is a little too advanced at this point and stem cell research is still dealing with a lot of unknown factors. Yeah they think that Parkinson's Alzheimer's, etc. can be helped with stem cell therapy because they're injecting stem cells in with other tissue mass which is a bit different than using stem cells to treat CF at this point (I'm talking about fixing the deletion, not directly injecting stem cells into the lungs).

The thing that differs CF from a patient having a stroke is that when a person has a stroke heart muscles weaken, etc. They put stem cells in there and they start strengthening the muscles. The same with Parkinson's, it's a particular area affected so if we theoretically put stem cells in there with healthy tissue they can become healthy tissue and function properly. We can't just inject our lungs with stem cells. Unfortunately we have a more difficult situation since it's not a BAM hit and run effect but a corrosive effect. The bugs/mucus/whatever that causes the weakness in the lungs is always there, without removing that injecting the lungs with stem cells wouldn't do crap diddly because we wouldn't be fixing the genetic mutation just fixing a symptom. After typing that up I googled it and found this <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/18121.php">http://www.medicalnewstoday.com/articles/18121.php</a> 4 years old.

With the lack of federal funding in the US there's not a lot being done here, which is definitely slowing research down. I think there's going to be more research into that particular area (stem cells [both embryonic and adult] and the body [as opposed to one particular organ]) due to new discoveries that have been happening. Like the girl who had a liver transplant whose blood type spontaneously changed to that of her donors. <a target=_blank class=ftalternatingbarlinklarge href="http://www.news.com.au/mercury/story/0,22884,23101546-5005940,00.html">http://www.news.com.au/mercury...101546-5005940,00.html</a> I think we don't hear about a lot of the recent stem cell stuff (like the fact that they have insulin producing mice now <a target=_blank class=ftalternatingbarlinklarge href="http://www.foxbusiness.com/article/novocell-reports-successful-use-stem-cells-generate-insulin-mice_487693_1.html">http://www.foxbusiness.com/art...lin-mice_487693_1.html</a> , can prevent kidney failure in rats <a target=_blank class=ftalternatingbarlinklarge href="http://www.stemcellnews.com/articles/stem-cells-kidney-failure.htm">http://www.stemcellnews.com/ar...lls-kidney-failure.htm</a> , and can produce functional liver cells <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/98428.php">http://www.medicalnewstoday.com/articles/98428.php</a> ) because a majority doesn't take place in the US.
 
I

IG

Guest
Afaik it's not going on with CF patients. I think CF is a little too advanced at this point and stem cell research is still dealing with a lot of unknown factors. Yeah they think that Parkinson's Alzheimer's, etc. can be helped with stem cell therapy because they're injecting stem cells in with other tissue mass which is a bit different than using stem cells to treat CF at this point (I'm talking about fixing the deletion, not directly injecting stem cells into the lungs).

The thing that differs CF from a patient having a stroke is that when a person has a stroke heart muscles weaken, etc. They put stem cells in there and they start strengthening the muscles. The same with Parkinson's, it's a particular area affected so if we theoretically put stem cells in there with healthy tissue they can become healthy tissue and function properly. We can't just inject our lungs with stem cells. Unfortunately we have a more difficult situation since it's not a BAM hit and run effect but a corrosive effect. The bugs/mucus/whatever that causes the weakness in the lungs is always there, without removing that injecting the lungs with stem cells wouldn't do crap diddly because we wouldn't be fixing the genetic mutation just fixing a symptom. After typing that up I googled it and found this <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/18121.php">http://www.medicalnewstoday.com/articles/18121.php</a> 4 years old.

With the lack of federal funding in the US there's not a lot being done here, which is definitely slowing research down. I think there's going to be more research into that particular area (stem cells [both embryonic and adult] and the body [as opposed to one particular organ]) due to new discoveries that have been happening. Like the girl who had a liver transplant whose blood type spontaneously changed to that of her donors. <a target=_blank class=ftalternatingbarlinklarge href="http://www.news.com.au/mercury/story/0,22884,23101546-5005940,00.html">http://www.news.com.au/mercury...101546-5005940,00.html</a> I think we don't hear about a lot of the recent stem cell stuff (like the fact that they have insulin producing mice now <a target=_blank class=ftalternatingbarlinklarge href="http://www.foxbusiness.com/article/novocell-reports-successful-use-stem-cells-generate-insulin-mice_487693_1.html">http://www.foxbusiness.com/art...lin-mice_487693_1.html</a> , can prevent kidney failure in rats <a target=_blank class=ftalternatingbarlinklarge href="http://www.stemcellnews.com/articles/stem-cells-kidney-failure.htm">http://www.stemcellnews.com/ar...lls-kidney-failure.htm</a> , and can produce functional liver cells <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/98428.php">http://www.medicalnewstoday.com/articles/98428.php</a> ) because a majority doesn't take place in the US.
 
I

IG

Guest
Afaik it's not going on with CF patients. I think CF is a little too advanced at this point and stem cell research is still dealing with a lot of unknown factors. Yeah they think that Parkinson's Alzheimer's, etc. can be helped with stem cell therapy because they're injecting stem cells in with other tissue mass which is a bit different than using stem cells to treat CF at this point (I'm talking about fixing the deletion, not directly injecting stem cells into the lungs).

The thing that differs CF from a patient having a stroke is that when a person has a stroke heart muscles weaken, etc. They put stem cells in there and they start strengthening the muscles. The same with Parkinson's, it's a particular area affected so if we theoretically put stem cells in there with healthy tissue they can become healthy tissue and function properly. We can't just inject our lungs with stem cells. Unfortunately we have a more difficult situation since it's not a BAM hit and run effect but a corrosive effect. The bugs/mucus/whatever that causes the weakness in the lungs is always there, without removing that injecting the lungs with stem cells wouldn't do crap diddly because we wouldn't be fixing the genetic mutation just fixing a symptom. After typing that up I googled it and found this <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/18121.php">http://www.medicalnewstoday.com/articles/18121.php</a> 4 years old.

With the lack of federal funding in the US there's not a lot being done here, which is definitely slowing research down. I think there's going to be more research into that particular area (stem cells [both embryonic and adult] and the body [as opposed to one particular organ]) due to new discoveries that have been happening. Like the girl who had a liver transplant whose blood type spontaneously changed to that of her donors. <a target=_blank class=ftalternatingbarlinklarge href="http://www.news.com.au/mercury/story/0,22884,23101546-5005940,00.html">http://www.news.com.au/mercury...101546-5005940,00.html</a> I think we don't hear about a lot of the recent stem cell stuff (like the fact that they have insulin producing mice now <a target=_blank class=ftalternatingbarlinklarge href="http://www.foxbusiness.com/article/novocell-reports-successful-use-stem-cells-generate-insulin-mice_487693_1.html">http://www.foxbusiness.com/art...lin-mice_487693_1.html</a> , can prevent kidney failure in rats <a target=_blank class=ftalternatingbarlinklarge href="http://www.stemcellnews.com/articles/stem-cells-kidney-failure.htm">http://www.stemcellnews.com/ar...lls-kidney-failure.htm</a> , and can produce functional liver cells <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/98428.php">http://www.medicalnewstoday.com/articles/98428.php</a> ) because a majority doesn't take place in the US.
 
I

IG

Guest
Afaik it's not going on with CF patients. I think CF is a little too advanced at this point and stem cell research is still dealing with a lot of unknown factors. Yeah they think that Parkinson's Alzheimer's, etc. can be helped with stem cell therapy because they're injecting stem cells in with other tissue mass which is a bit different than using stem cells to treat CF at this point (I'm talking about fixing the deletion, not directly injecting stem cells into the lungs).

The thing that differs CF from a patient having a stroke is that when a person has a stroke heart muscles weaken, etc. They put stem cells in there and they start strengthening the muscles. The same with Parkinson's, it's a particular area affected so if we theoretically put stem cells in there with healthy tissue they can become healthy tissue and function properly. We can't just inject our lungs with stem cells. Unfortunately we have a more difficult situation since it's not a BAM hit and run effect but a corrosive effect. The bugs/mucus/whatever that causes the weakness in the lungs is always there, without removing that injecting the lungs with stem cells wouldn't do crap diddly because we wouldn't be fixing the genetic mutation just fixing a symptom. After typing that up I googled it and found this <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/18121.php">http://www.medicalnewstoday.com/articles/18121.php</a> 4 years old.

With the lack of federal funding in the US there's not a lot being done here, which is definitely slowing research down. I think there's going to be more research into that particular area (stem cells [both embryonic and adult] and the body [as opposed to one particular organ]) due to new discoveries that have been happening. Like the girl who had a liver transplant whose blood type spontaneously changed to that of her donors. <a target=_blank class=ftalternatingbarlinklarge href="http://www.news.com.au/mercury/story/0,22884,23101546-5005940,00.html">http://www.news.com.au/mercury...101546-5005940,00.html</a> I think we don't hear about a lot of the recent stem cell stuff (like the fact that they have insulin producing mice now <a target=_blank class=ftalternatingbarlinklarge href="http://www.foxbusiness.com/article/novocell-reports-successful-use-stem-cells-generate-insulin-mice_487693_1.html">http://www.foxbusiness.com/art...lin-mice_487693_1.html</a> , can prevent kidney failure in rats <a target=_blank class=ftalternatingbarlinklarge href="http://www.stemcellnews.com/articles/stem-cells-kidney-failure.htm">http://www.stemcellnews.com/ar...lls-kidney-failure.htm</a> , and can produce functional liver cells <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/98428.php">http://www.medicalnewstoday.com/articles/98428.php</a> ) because a majority doesn't take place in the US.
 
I

IG

Guest
Afaik it's not going on with CF patients. I think CF is a little too advanced at this point and stem cell research is still dealing with a lot of unknown factors. Yeah they think that Parkinson's Alzheimer's, etc. can be helped with stem cell therapy because they're injecting stem cells in with other tissue mass which is a bit different than using stem cells to treat CF at this point (I'm talking about fixing the deletion, not directly injecting stem cells into the lungs).
<br />
<br />The thing that differs CF from a patient having a stroke is that when a person has a stroke heart muscles weaken, etc. They put stem cells in there and they start strengthening the muscles. The same with Parkinson's, it's a particular area affected so if we theoretically put stem cells in there with healthy tissue they can become healthy tissue and function properly. We can't just inject our lungs with stem cells. Unfortunately we have a more difficult situation since it's not a BAM hit and run effect but a corrosive effect. The bugs/mucus/whatever that causes the weakness in the lungs is always there, without removing that injecting the lungs with stem cells wouldn't do crap diddly because we wouldn't be fixing the genetic mutation just fixing a symptom. After typing that up I googled it and found this <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/18121.php">http://www.medicalnewstoday.com/articles/18121.php</a> 4 years old.
<br />
<br />With the lack of federal funding in the US there's not a lot being done here, which is definitely slowing research down. I think there's going to be more research into that particular area (stem cells [both embryonic and adult] and the body [as opposed to one particular organ]) due to new discoveries that have been happening. Like the girl who had a liver transplant whose blood type spontaneously changed to that of her donors. <a target=_blank class=ftalternatingbarlinklarge href="http://www.news.com.au/mercury/story/0,22884,23101546-5005940,00.html">http://www.news.com.au/mercury...101546-5005940,00.html</a> I think we don't hear about a lot of the recent stem cell stuff (like the fact that they have insulin producing mice now <a target=_blank class=ftalternatingbarlinklarge href="http://www.foxbusiness.com/article/novocell-reports-successful-use-stem-cells-generate-insulin-mice_487693_1.html">http://www.foxbusiness.com/art...lin-mice_487693_1.html</a> , can prevent kidney failure in rats <a target=_blank class=ftalternatingbarlinklarge href="http://www.stemcellnews.com/articles/stem-cells-kidney-failure.htm">http://www.stemcellnews.com/ar...lls-kidney-failure.htm</a> , and can produce functional liver cells <a target=_blank class=ftalternatingbarlinklarge href="http://www.medicalnewstoday.com/articles/98428.php">http://www.medicalnewstoday.com/articles/98428.php</a> ) because a majority doesn't take place in the US.
 
F

Faust

New member
Cool thanks for the info immortal. Yeah, I knew that injecting stem cells into our lungs wouldn't "cure" us due to our mutations. I was just wondering why (still am to some extent) why injecting stem cells into our lungs to repair damaged tissue (that we all have) to prolong our lives and give us better quality of life. Since we see this with damaged hearts...Explain to me (possibly again) why this couldn't be used as a treatment periodically to help us with our damage?


I'd sign up right now if there was a trial like this and I qualified.
 
F

Faust

New member
Cool thanks for the info immortal. Yeah, I knew that injecting stem cells into our lungs wouldn't "cure" us due to our mutations. I was just wondering why (still am to some extent) why injecting stem cells into our lungs to repair damaged tissue (that we all have) to prolong our lives and give us better quality of life. Since we see this with damaged hearts...Explain to me (possibly again) why this couldn't be used as a treatment periodically to help us with our damage?


I'd sign up right now if there was a trial like this and I qualified.
 
F

Faust

New member
Cool thanks for the info immortal. Yeah, I knew that injecting stem cells into our lungs wouldn't "cure" us due to our mutations. I was just wondering why (still am to some extent) why injecting stem cells into our lungs to repair damaged tissue (that we all have) to prolong our lives and give us better quality of life. Since we see this with damaged hearts...Explain to me (possibly again) why this couldn't be used as a treatment periodically to help us with our damage?


I'd sign up right now if there was a trial like this and I qualified.
 
F

Faust

New member
Cool thanks for the info immortal. Yeah, I knew that injecting stem cells into our lungs wouldn't "cure" us due to our mutations. I was just wondering why (still am to some extent) why injecting stem cells into our lungs to repair damaged tissue (that we all have) to prolong our lives and give us better quality of life. Since we see this with damaged hearts...Explain to me (possibly again) why this couldn't be used as a treatment periodically to help us with our damage?


I'd sign up right now if there was a trial like this and I qualified.
 
F

Faust

New member
Cool thanks for the info immortal. Yeah, I knew that injecting stem cells into our lungs wouldn't "cure" us due to our mutations. I was just wondering why (still am to some extent) why injecting stem cells into our lungs to repair damaged tissue (that we all have) to prolong our lives and give us better quality of life. Since we see this with damaged hearts...Explain to me (possibly again) why this couldn't be used as a treatment periodically to help us with our damage?
<br />
<br />
<br />I'd sign up right now if there was a trial like this and I qualified.
<br />
<br />
<br />
 
I

IG

Guest
No problem, as to why not? I think it's possible to do that but there's a lot 'against' it. It would be like sticking your fingers in a dike to stop a leak and have 6 other leaks start. It's not really a cure and as far as they know it's not really therapeutics, which is akin to being stuck between a rock and a hard place because until you have trials you won't know if it's therapeutic and you can't have trials until there's some evidence that it'll work. I know they test a lot of drugs on CF tissue (like nasal tissue with viagra study) but I'm not sure it's possible to reproduce the genetic CF lung effect in mice.. I haven't looked that up so it's entirely possible that it is.

Another factor might be that the lungs are bigger.. with stroke victims and others you're generally dealing with an isolated area, so the lungs are broader and you're treating the whole lungs which means more uncertainty. It would be possible to test a smaller area but that area would be compromised in a study by the rest of your 'contaminated' lungs. Plus to keep the area healthy, if it does work, would probably require a therapeutic maintenance of stem cells.. and since it would be embryonic that would be even more difficult unless they found a way to manipulate adult stem cells, or cord cells, to work in that situation.

Another thing, and probably the biggest argument, is that even now using stem cells to repair heart damage isn't the norm, it's still experimental so even getting the go ahead to theoretically try something like this would be difficult... and you would have to either go over seas where stem cell research is funded by the government or go to one of the privately owned research labs that deal with stem cell research... Gee I sound so overly optimistic. I think it would be great if this ever did happen but since embryonic stem cells are so ethically debatable it's hard to find middle ground and still move forward with research. Though they are trying to find a way around that ( <a target=_blank class=ftalternatingbarlinklarge href="http://www.msnbc.msn.com/id/22594571/">http://www.msnbc.msn.com/id/22594571/</a> )
 
I

IG

Guest
No problem, as to why not? I think it's possible to do that but there's a lot 'against' it. It would be like sticking your fingers in a dike to stop a leak and have 6 other leaks start. It's not really a cure and as far as they know it's not really therapeutics, which is akin to being stuck between a rock and a hard place because until you have trials you won't know if it's therapeutic and you can't have trials until there's some evidence that it'll work. I know they test a lot of drugs on CF tissue (like nasal tissue with viagra study) but I'm not sure it's possible to reproduce the genetic CF lung effect in mice.. I haven't looked that up so it's entirely possible that it is.

Another factor might be that the lungs are bigger.. with stroke victims and others you're generally dealing with an isolated area, so the lungs are broader and you're treating the whole lungs which means more uncertainty. It would be possible to test a smaller area but that area would be compromised in a study by the rest of your 'contaminated' lungs. Plus to keep the area healthy, if it does work, would probably require a therapeutic maintenance of stem cells.. and since it would be embryonic that would be even more difficult unless they found a way to manipulate adult stem cells, or cord cells, to work in that situation.

Another thing, and probably the biggest argument, is that even now using stem cells to repair heart damage isn't the norm, it's still experimental so even getting the go ahead to theoretically try something like this would be difficult... and you would have to either go over seas where stem cell research is funded by the government or go to one of the privately owned research labs that deal with stem cell research... Gee I sound so overly optimistic. I think it would be great if this ever did happen but since embryonic stem cells are so ethically debatable it's hard to find middle ground and still move forward with research. Though they are trying to find a way around that ( <a target=_blank class=ftalternatingbarlinklarge href="http://www.msnbc.msn.com/id/22594571/">http://www.msnbc.msn.com/id/22594571/</a> )
 
I

IG

Guest
No problem, as to why not? I think it's possible to do that but there's a lot 'against' it. It would be like sticking your fingers in a dike to stop a leak and have 6 other leaks start. It's not really a cure and as far as they know it's not really therapeutics, which is akin to being stuck between a rock and a hard place because until you have trials you won't know if it's therapeutic and you can't have trials until there's some evidence that it'll work. I know they test a lot of drugs on CF tissue (like nasal tissue with viagra study) but I'm not sure it's possible to reproduce the genetic CF lung effect in mice.. I haven't looked that up so it's entirely possible that it is.

Another factor might be that the lungs are bigger.. with stroke victims and others you're generally dealing with an isolated area, so the lungs are broader and you're treating the whole lungs which means more uncertainty. It would be possible to test a smaller area but that area would be compromised in a study by the rest of your 'contaminated' lungs. Plus to keep the area healthy, if it does work, would probably require a therapeutic maintenance of stem cells.. and since it would be embryonic that would be even more difficult unless they found a way to manipulate adult stem cells, or cord cells, to work in that situation.

Another thing, and probably the biggest argument, is that even now using stem cells to repair heart damage isn't the norm, it's still experimental so even getting the go ahead to theoretically try something like this would be difficult... and you would have to either go over seas where stem cell research is funded by the government or go to one of the privately owned research labs that deal with stem cell research... Gee I sound so overly optimistic. I think it would be great if this ever did happen but since embryonic stem cells are so ethically debatable it's hard to find middle ground and still move forward with research. Though they are trying to find a way around that ( <a target=_blank class=ftalternatingbarlinklarge href="http://www.msnbc.msn.com/id/22594571/">http://www.msnbc.msn.com/id/22594571/</a> )
 
I

IG

Guest
No problem, as to why not? I think it's possible to do that but there's a lot 'against' it. It would be like sticking your fingers in a dike to stop a leak and have 6 other leaks start. It's not really a cure and as far as they know it's not really therapeutics, which is akin to being stuck between a rock and a hard place because until you have trials you won't know if it's therapeutic and you can't have trials until there's some evidence that it'll work. I know they test a lot of drugs on CF tissue (like nasal tissue with viagra study) but I'm not sure it's possible to reproduce the genetic CF lung effect in mice.. I haven't looked that up so it's entirely possible that it is.

Another factor might be that the lungs are bigger.. with stroke victims and others you're generally dealing with an isolated area, so the lungs are broader and you're treating the whole lungs which means more uncertainty. It would be possible to test a smaller area but that area would be compromised in a study by the rest of your 'contaminated' lungs. Plus to keep the area healthy, if it does work, would probably require a therapeutic maintenance of stem cells.. and since it would be embryonic that would be even more difficult unless they found a way to manipulate adult stem cells, or cord cells, to work in that situation.

Another thing, and probably the biggest argument, is that even now using stem cells to repair heart damage isn't the norm, it's still experimental so even getting the go ahead to theoretically try something like this would be difficult... and you would have to either go over seas where stem cell research is funded by the government or go to one of the privately owned research labs that deal with stem cell research... Gee I sound so overly optimistic. I think it would be great if this ever did happen but since embryonic stem cells are so ethically debatable it's hard to find middle ground and still move forward with research. Though they are trying to find a way around that ( <a target=_blank class=ftalternatingbarlinklarge href="http://www.msnbc.msn.com/id/22594571/">http://www.msnbc.msn.com/id/22594571/</a> )
 
I

IG

Guest
No problem, as to why not? I think it's possible to do that but there's a lot 'against' it. It would be like sticking your fingers in a dike to stop a leak and have 6 other leaks start. It's not really a cure and as far as they know it's not really therapeutics, which is akin to being stuck between a rock and a hard place because until you have trials you won't know if it's therapeutic and you can't have trials until there's some evidence that it'll work. I know they test a lot of drugs on CF tissue (like nasal tissue with viagra study) but I'm not sure it's possible to reproduce the genetic CF lung effect in mice.. I haven't looked that up so it's entirely possible that it is.
<br />
<br />Another factor might be that the lungs are bigger.. with stroke victims and others you're generally dealing with an isolated area, so the lungs are broader and you're treating the whole lungs which means more uncertainty. It would be possible to test a smaller area but that area would be compromised in a study by the rest of your 'contaminated' lungs. Plus to keep the area healthy, if it does work, would probably require a therapeutic maintenance of stem cells.. and since it would be embryonic that would be even more difficult unless they found a way to manipulate adult stem cells, or cord cells, to work in that situation.
<br />
<br />Another thing, and probably the biggest argument, is that even now using stem cells to repair heart damage isn't the norm, it's still experimental so even getting the go ahead to theoretically try something like this would be difficult... and you would have to either go over seas where stem cell research is funded by the government or go to one of the privately owned research labs that deal with stem cell research... Gee I sound so overly optimistic. I think it would be great if this ever did happen but since embryonic stem cells are so ethically debatable it's hard to find middle ground and still move forward with research. Though they are trying to find a way around that ( <a target=_blank class=ftalternatingbarlinklarge href="http://www.msnbc.msn.com/id/22594571/">http://www.msnbc.msn.com/id/22594571/</a> )
 
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