I'm not sure about the Zithromax, but I do know that Cipro should not be taken with calcium or multivitamins (like ADEK, if you take that). The best thing to do would be to call your pharmacist, or ANY pharmacist for that matter, and just ask them if they're safe to take together. This way, you'll know for sure - good luck <img src="i/expressions/face-icon-small-happy.gif" border="0">