Hi Piper. I get achy and headachy all the time, especially in my legs. I just generally hurt all over and feel like crap! I take Ibuprofen 600mg twice a day every day. I can't live without the stuff! I tried Tylenol, but it just didn't do the trick. I've been on Ibuprofen for years and years now. I asked my CF doc about it when this all started and he said to take it when I needed it. Also, I think Ibuprofen is taken sometimes in high doses to help inflammation in the lungs? Don't quote me on that, I don't know all the details. You should talk to your CF doc about it though and see what he/she says. I've never been told I have CF related arthritis, but I've never asked either. I always just assumed I had poor circulation. Good luck and I hope you feel better.Martha 29, CF