vx770 trial results

[john81john]

Hi there, I have read through the NEJM G551D article figures... and I found several data very interesting...

1) there were very big improvements in sweat chloride concentrations from baseline to day 28 (people with 150mg or 250 mg drug): 9x very good improvement (40-65 points down), 2x good improvement(35 points down), 4x lower improvement (10-25 points down)

2) there were very different changes in FEV1 %: 3x very good improvement (more than +15--+30%!), 4x good improvement (+10--+15%), 4 x small improvement (+4%--+7%), 4x very small improvement (0--+3%)

3)there is no direct connection between sweat chloride concentrations improvement and FEV1% improvement... 9 people had very great sweat chloride impr., but only 3 people had great FEV1% impr. (of course its different if someone has baseline 85% and he can change it to 100% or someone who has 45% and can improve to 60%)

My conclusion /and only my personal - with maybe some mistakes and tolerance in data showed/ is (have to say that more important for me was FEV1% change)

: 25% people have very good reaction on VX770,
: 35% has good reaction on VX770,
: 40% has small reaction on VX770 (but there is still few % improvement too )

what do you think?

 

[john81john]

Hi there, I have read through the NEJM G551D article figures... and I found several data very interesting...
<br />
<br />1) there were very big improvements in sweat chloride concentrations from baseline to day 28 (people with 150mg or 250 mg drug): 9x very good improvement (40-65 points down), 2x good improvement(35 points down), 4x lower improvement (10-25 points down)
<br />
<br />2) there were very different changes in FEV1 %: 3x very good improvement (more than +15--+30%!), 4x good improvement (+10--+15%), 4 x small improvement (+4%--+7%), 4x very small improvement (0--+3%)
<br />
<br />3)there is no direct connection between sweat chloride concentrations improvement and FEV1% improvement... 9 people had very great sweat chloride impr., but only 3 people had great FEV1% impr. (of course its different if someone has baseline 85% and he can change it to 100% or someone who has 45% and can improve to 60%)
<br />
<br />My conclusion /and only my personal - with maybe some mistakes and tolerance in data showed/ is (have to say that more important for me was FEV1% change)
<br />
<br />: 25% people have very good reaction on VX770,
<br />: 35% has good reaction on VX770,
<br />: 40% has small reaction on VX770 (but there is still few % improvement too )
<br />
<br />what do you think?

 

[dasjsmum]

well, I dont know, but I (ahem) THINK the 770 will improve some people's pancreatic function <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[dasjsmum]

well, I dont know, but I (ahem) THINK the 770 will improve some people's pancreatic function <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[dasjsmum]

well, I dont know, but I (ahem) THINK the 770 will improve some people's pancreatic function <img src="i/expressions/face-icon-small-wink.gif" border="0">

 

[LouLou]

Also, it's important to remember that a 10% increase for someone with a 65% FEV1 is not to 75% but rather 71.5%

This is something that is very often miss understood in the cf community.

 

[LouLou]

Also, it's important to remember that a 10% increase for someone with a 65% FEV1 is not to 75% but rather 71.5%

This is something that is very often miss understood in the cf community.

 

[LouLou]

Also, it's important to remember that a 10% increase for someone with a 65% FEV1 is not to 75% but rather 71.5%
<br />
<br />This is something that is very often miss understood in the cf community.