<div class="FTQUOTE"><begin quote><i>Originally posted by: <b>rvm1212</b></i>
dramamama, do you have any clue on when denufosol will be out in the market?
I have another question. Is acetylcysteine the same as N-acetylcysteine.? I think so , but i am not sure. I´m from spain and here we only have acetylcysteine, which you have to get with a prescription and comes in fizzy tablets of 600. (flumil 600). I think acetylcysteine(acetilcisteina), is the spanish name for n-acetylcysteine, but I am not sure. Here is used as a mucolytic and also for paracetamol intoxication.
Rita</end quote></div>
hi Rita.
About the release of Denufosol. Originally they were planning for a late Fall 2009, but after speaking with a doc yesterday, he believes it will not be available until late 2010 due to the fact the trial is having a hard time filling up here in the US. Many people do not know about it and/or are not comfortable being involved in a trial. Also, many of the healthiest needed to participate are young and some parents are afraid of the thought or do not want to subject their children to the rigors of a clinical trial....which is totally understandable. At any rate, the trial is lagging and the cut off is very specific..fev1 above 75%, no bad bugs (only pseudo and possibly MRSA) and willing to take the inhaled drug 3 times a day.
As far as the NAC goes, I found this on wikipedia.
This is from wikipedia...
Acetylcysteine
From Wikipedia, the free encyclopedia
(Redirected from Mucomyst)
Acetylcysteine
Systematic (IUPAC) name
(R)-2-acetamido-3-mercaptopropanoic acid
Identifiers
CAS number 616-91-1
ATC code R05CB01 S01XA08 V03AB23
PubChem 12035
DrugBank n/a
Chemical data
Formula C5H9NO3S
Mol. mass 163.19
Pharmacokinetic data
Bioavailability 6 - 10% (oral)
<3% (topical)
Metabolism hepatic
Half life 5.6 hours (adults)
11 hours (neonates)
Excretion renal
Therapeutic considerations
Licence data
US
Routes inhalation, IV, oral
Acetylcysteine (rINN) (IPA: [?æs?tl??s?stin, ??s?tl?-, ?æs?ta?l-]), also known as N-acetylcysteine (abbreviated NAC), is a pharmacological agent used mainly as a mucolytic and in the management of paracetamol/acetaminophen overdose. For these indications, acetylcysteine is available under the trade names ACC (Hexal AG), Mucomyst (Bristol-Myers Squibb), Acetadote (Cumberland Pharmaceuticals), Fluimucil and Parvolex (GSK).