From what I've read, Prevacid is fine to take with antibiotics- it is even prescribed in a "PrevPac" for treating H. pylori infection (prevacid taken with an antibiotic) to improve the effectiveness (somehow!) of the antibiotic... Antacids (Tums, Rolaids, etc...) that contain calcium or minerals can interfer with the absorbtion of antibiotics.
I went from taking Cotazyme as a kid (did not help the oil issue!), to nothing as a teenager and young adult (apparently, I was and am still, for the most part, pancreatic sufficent), and now I take a Viokase 16 when I eat a greasy meal (...Outback bloomin onion? <img src="i/expressions/face-icon-small-wink.gif" border="0"> ) and take Nexium with dinner, and bingo! <i>Rarely </i>ever a problem (as long as I remember to take them).
I have tried several other enzymes (but they didn't help the greasy meal and it's after affects, just gave me gas and made me cramp up), and I am so happy to have been given this one by my (new) GI! <img src="i/expressions/face-icon-small-smile.gif" border="0"> You may just need to keep trying something else until you find one that helps the most. Good luck- that is so aggravating!!!!