I take aquADEK's and about in 2007 my mom and I were arguing b/c she wanted me to take an enzyme with abx, and I told her there was no reason so we asked my doctor and she said, abx are digested differently so no enzymes w/ those, but did bring up that, yes, you should should w/ vitamins. She said it is best to take them with a meal with enzymes (obviously) b/c they are fat soluable. Otherwise, if I take them separately, I take just one enzyme w/ all my vitamins (I take Ultrase MT 20's or Zen Pen now though).
Another example of when to take an enzyme is maranol, the marjuina derived appetite stimulant, is in sesame oil or something like that, so when I was trying that, I had to take an enzyme with it and was told directly by my doctors that.