I alway give Maggie enzymes with milk...She drinks whole milk, our chocholate milk is Ovaltime with whole milk and I would give her 2-3 enzymes with it..If I didn't she'ld either throw up or have a tummy ache. She is severely pancreatic insufficient though. But for swiss miss with water maybe one enzyme, like Liza said? I'm always looking for more calories so I'ld mix it with whole milk.