I certainly can't speak for everyone, but in my observations, it seems that people with only one DF508 (or two different mutations, not to include the DF508) have less severe CF. I know some will jump all over that and yell about how every patient is different and you can't generalize and I agree, for the most part. But based on the severity of disease of people on this very site, DoubleDelta's seem to be worse off, IMO.